ArticleArthritis care & research2017
Association Between Menopausal Factors and the Risk of Seronegative and Seropositive Rheumatoid Arthritis: Results From the Nurses' Health Studies.
Article in Arthritis care & research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- Postural Orthostatic Tachycardia Syndrome, Menopause and Hormone Replacement Therapy: Clinical Decisions in Times of Uncertainty.Journal of clinical medicine · 2026Review
- Global Disability and Economic Burden Caused by Rheumatoid Arthritis, Osteoarthritis, Neck Pain, and Low Back Pain in Women of Childbearing Age from 1990 to 2021.International journal of women's health · 2026Article
- Cost-effectiveness and public health impact of influenza vaccination strategies for Chinese patients with rheumatoid arthritis.Human vaccines & immunotherapeutics · 2025Article
- Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2025Review
- The Therapeutic Potential of Phytochemicals Unlocks New Avenues in the Management of Rheumatoid Arthritis.International journal of molecular sciences · 2025Review
- Prevalence of rheumatoid arthritis in China: Variations and trends from the global burden of disease study 2021.Rheumatology and immunology research · 2025Article
- Shorter reproductive time span and early menopause increase the risk of ACPA-negative inflammatory arthritis in postmenopausal women with clinically suspect arthralgia.Rheumatology (Oxford, England) · 2025Article
- Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis.BMC women's health · 2025Observational
- Impact of Sex, Serostatus, and Smoking on Risk for Rheumatoid Arthritis-Associated Interstitial Lung Disease Subtypes.Arthritis care & research · 2025Article
- Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis Treatment: A Comprehensive Review.Current rheumatology reviews · 2025Review
- Unveiling health inequalities and frontier gaps in elderly-onset rheumatoid arthritis: evolving impact of smoking and future challenges.Frontiers in medicine · 2025Article
- Menopausal state and rheumatoid arthritis: a systematic review and meta-analysis.BMC rheumatology · 2024Article
- Impact of frailty severity and severe pain on cognitive function for community-dwelling older adults with arthritis: a cross-sectional study in Korea.Scientific reports · 2024Article
- Article
- Global, regional, and national burdens of rheumatoid arthritis in young adults from 1990 to 2019.Archives of medical science : AMS · 2024Article
- Complex role of oestrogens in the risk and severity of rheumatoid arthritis in menopause.RMD open · 2023Article
- Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis.Prostaglandins, leukotrienes, and essential fatty acids · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset.Rheumatology (Oxford, England) · 2022Article
- Long-term weight changes and risk of rheumatoid arthritis among women in a prospective cohort: a marginal structural model approach.Rheumatology (Oxford, England) · 2022Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate whether menopausal factors are associated with the development of serologic rheumatoid arthritis (RA) phenotypes.
methodsData were analyzed from the Nurses' Health Studies (NHS; 1976-2010 and NHSII 1989-2011). A total of 120,700 female nurses ages 30-55 years in the NHS, and a total of 116,430 female nurses ages 25-42 years in the NHSII, were followed via biennial questionnaires on lifestyle and disease outcomes. In total, 1,096 incident RA cases were confirmed by questionnaire and chart review. Seropositive RA was defined as rheumatoid factor positive (RF) or antibodies to citrullinated protein antigen (ACPA) positive, and seronegative RA was defined as RF negative and ACPA negative. We used Cox proportional hazards models to obtain multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) of seropositive/seronegative RA associated with menopausal status, age at menopause, type of menopause, ovulatory years, and postmenopausal hormone therapy (PMH) use.
resultsPostmenopausal women had a 2-fold increased risk of seronegative RA, compared with premenopausal women (NHS: HR 1.8 [95% CI 1.1-3.0], NHSII: HR 2.4 [95% CI 1.4-3.9], and pooled HR 2.1 [95% CI 1.4-3.0]). Natural menopause at early age (≤44 years) was associated with an increased risk of seronegative RA (pooled HR 2.4 [95% CI 1.5-4.0]). None of the menopausal factors was significantly associated with seropositive RA. We observed no association between PMH use and the risk of seronegative or seropositive RA, except that PMH use of ≥8 years was associated with increased risk of seropositive RA (pooled HR 1.4 [95% CI 1.1-1.9]).
conclusionPostmenopause and natural menopause at an early age were strongly associated with seronegative RA, but only marginally with seropositive RA, suggesting potential differences in the etiology of RA subtypes.
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