ArticlePediatric research2017
Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Fulminant necrotizing enterocolitis: clinical features and a predictive model.BMC pediatrics · 2025Article
- Development and validation of a nomogram model for predicting the occurrence of necrotizing enterocolitis in premature infants with late-onset sepsis.European journal of medical research · 2025Article
- Rapidly progressive necrotizing enterocolitis: Risk factors and a predictive model.Pediatric research · 2025Article
- Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates.Frontiers in pediatrics · 2025Article
- Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis.Pediatric research · 2024Article
- The Potential Value of Mean Platelet Volume and Platelet Distribution Width as Inflammatory Indicators in Surgical Necrotizing Enterocolitis.Journal of inflammation research · 2024Article
- Association of anemia and platelet activation with necrotizing enterocolitis with or without sepsis among low birth weight neonates: a case-control study.Frontiers in pediatrics · 2023Article
- Gestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- An improved joint non-negative matrix factorization for identifying surgical treatment timing of neonatal necrotizing enterocolitis.Bosnian journal of basic medical sciences · 2022Article
- Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis.Nature reviews. Gastroenterology & hepatology · 2022Review
- The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants.International journal of general medicine · 2022Article
- Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Role of platelets in neonatal necrotizing enterocolitis.Pediatric research · 2021Review
- Prenatal stress increases IgA coating of offspring microbiota and exacerbates necrotizing enterocolitis-like injury in a sex-dependent manner.Brain, behavior, and immunity · 2020Article
- Precision-based modeling approaches for necrotizing enterocolitis.Disease models & mechanisms · 2020Review
- Recent Advances in Necrotizing Enterocolitis Research: Strategies for Implementation in Clinical Practice.Clinics in perinatology · 2020Review
- Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The science and necessity of using animal models in the study of necrotizing enterocolitis.Seminars in pediatric surgery · 2018Review
- The Phylogeny, Ontogeny, and Organ-specific Differentiation of Macrophages in the Developing Intestine.Newborn (Clarksville, Md.)Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThrombocytopenia is frequently encountered in infants with necrotizing enterocolitis (NEC). To develop a preclinical model of NEC-related thrombocytopenia, we measured serial platelet counts in 10-d-old (P10) mouse pups with trinitrobenzene sulfonic acid (TNBS)-induced NEC-like injury. We also measured platelet volume indices, immature platelet fraction (IPF), and megakaryocyte number/ploidy in these animals.
methodsPlatelet counts, platelet volume indices, and IPF were measured in control (N = 65) and TNBS-treated pups (N = 104) using an automated hematology analyzer. Bone marrow megakaryocyte number, ploidy and CD41 expression were measured by flow cytometry. These findings were confirmed in a small cohort of P3 mice with NEC-like injury.
resultsMurine pups with TNBS-mediated NEC-like injury developed thrombocytopenia at 15-24 h after exposure to TNBS. Intestinal injury was associated with increased platelet volume indices (mean platelet volume, platelet-to-large cell ratio, and platelet distribution width), and IPF, indicating increased thrombopoiesis. These mice also showed increased megakaryocyte number, ploidy, and CD41 expression, indicating increased megakaryocyte differentiation.
conclusionSimilar to human NEC, murine NEC-like injury was also associated with decreased platelet counts. There was evidence of increased megakaryocyte differentiation and thrombopoiesis, which favors peripheral consumption of platelets as the likely mechanism of thrombocytopenia in these animals, over decreased platelet production.
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