Evidence map›Paper›PMID 28085630›Full record

ArticleChannels (Austin, Tex.)2017

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4.

Constanza Alcaino, Kaitlyn Knutson, Philip A Gottlieb, Gianrico Farrugia, Arthur Beyder

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Yoda molecules agonize PIEZO2.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Pharmacology of PIEZO1 channels.British journal of pharmacology · 2024
    Review
  12. Review
  13. Article
  14. Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  15. Article
  16. Piezo channels in the intestinal tract.Frontiers in physiology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Constanza Alcainoa Department of Physiology & Biomedical Engineering, Enteric Neuroscience Program, Division of Gastroenterology & Hepatology , Mayo Clinic , Rochester , MN , USA.
Kaitlyn Knutsona Department of Physiology & Biomedical Engineering, Enteric Neuroscience Program, Division of Gastroenterology & Hepatology , Mayo Clinic , Rochester , MN , USA.
Philip A Gottliebb Department of Physiology and Biophysics, Center for Single Molecule Biophysics , State University of New York , Buffalo , NY , USA.
Gianrico Farrugiab Department of Physiology and Biophysics, Center for Single Molecule Biophysics , State University of New York , Buffalo , NY , USA.
Arthur Beydera Department of Physiology & Biomedical Engineering, Enteric Neuroscience Program, Division of Gastroenterology & Hepatology , Mayo Clinic , Rochester , MN , USA.
Mayo Clinic in Arizona · USUniversity at Buffalo, State University of New York · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2M
Mechanisms of mechanotransduction in the enterochromaffin cellsK08DK106456 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2015 to 2019
$813k
NIDDK NIH HHS K08 DK106456NIDDK NIH HHS P30 DK084567
6 · The paper itself

Abstract

Enterochromaffin (

Indexed as

Biomechanical PhenomenaDose-Response Relationship, DrugHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsIon ChannelsMechanotransduction, CellularPeptidesSpider VenomsIntercellular Signaling Peptides and ProteinsIon ChannelsMTx4 protein, Grammostola spatulataPeptidesPIEZO2 protein, humanSpider VenomsD-GsMTx4enterochromaffin cellmechanosensitive ion channelmechanotransductionPiezo2

Identifiers

PMID28085630
PMCPMC5463886
OpenAlexW2575510219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.