Evidence map›Paper›PMID 28085493›Full record

ReviewAmerican journal of respiratory cell and molecular biology2017

Metabolism and Skeletal Muscle Homeostasis in Lung Disease.

Ermelinda Ceco, Samuel E Weinberg, Navdeep S Chandel, Jacob I Sznajder

Abstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. m6A demethylase FTO and osteoporosis: potential therapeutic interventions.Frontiers in cell and developmental biology · 2023
    Review
  6. Article
  7. Article
  8. Plant-DerivedNutrients · 2021
    Article
  9. Review
  10. Article
  11. Elevated COFrontiers in physiology · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ermelinda CecoDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
Samuel E WeinbergDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
Navdeep S ChandelDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-2089-4764
Northwestern University · US

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
The injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9M
NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL085534NHLBI NIH HHS T32 HL076139NIA NIH HHS P01 AG049665
6 · The paper itself

Abstract

There is increased awareness that patients with lung diseases develop muscle dysfunction. Muscle dysfunction is a major contributor to a decreased quality of life in patients with chronic pulmonary diseases. Furthermore, muscle dysfunction exacerbates lung disease outcome, as a decrease in muscle mass and function are associated with increased morbidity, often long after critical illness or lung disease has been resolved. As we are learning more about the role of metabolism in health and disease, we are appreciating more the direct role of metabolism in skeletal muscle homeostasis. Altered metabolism is associated with numerous skeletal muscle pathologies and, conversely, skeletal muscle diseases are associated with significant changes in metabolic pathways. In this review, we highlight the role of metabolism in the regulation of skeletal muscle homeostasis. Understanding the metabolic pathways that underlie skeletal muscle wasting is of significant clinical interest for critically ill patients as well as patients with chronic lung disease, in which proper skeletal muscle function is essential to disease outcome.

Indexed as

HomeostasisAnimalsEnergy MetabolismHealthHumansLung DiseasesMuscle, SkeletalMuscular Diseasesacute respiratory distress syndromechronic obstructive pulmonary diseasemetabolic maladaptationssatellite cellsskeletal muscle homeostasis

Identifiers

PMID28085493
PMCPMC5516279
OpenAlexW2588224359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.