ArticleThe Journal of cell biology1989
The complete sequence of Drosophila alpha-spectrin: conservation of structural domains between alpha-spectrins and alpha-actinin.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 95 citations in OpenAlex.
- Axonal Spectrins: Nanoscale Organization, Functional Domains and Spectrinopathies.Frontiers in cellular neuroscience · 2019Review
- αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation.Cell and tissue research · 2018Article
- The role of βII spectrin in cardiac health and disease.Life sciences · 2018Review
- Spectrin-based skeleton as an actor in cell signaling.Cellular and molecular life sciences : CMLS · 2012Review
- Transgene rescue identifies an essential function for Drosophila beta spectrin in the nervous system and a selective requirement for ankyrin-2-binding activity.Molecular biology of the cell · 2010Article
- Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.The Journal of cell biology · 2006Article
- Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.The Journal of cell biology · 2000Article
- Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles.The Journal of cell biology · 1996Article
- Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.The EMBO journal · 1995Article
- Drosophila development requires spectrin network formation.The Journal of cell biology · 1995Article
- Interchain binding at the tail end of the Drosophila spectrin molecule.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.The EMBO journal · 1994Article
- Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster.The Journal of cell biology · 1993Article
- Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The complete sequence of Drosophila beta-spectrin reveals supra-motifs comprising eight 106-residue segments.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Analysis of the three-alpha-helix motif in the spectrin superfamily of proteins.Biophysical journal · 1992Article
- Phasing the conformational unit of spectrin.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report the complete sequence of Drosophila alpha-spectrin and show that it is similar to vertebrate nonerythroid spectrins. As in vertebrates, the alpha subunit consists of two large domains of repetitive sequence (segments 1-9 and 11-19) separated by a short nonrepetitive sequence (segment 10). The 106-residue repetitive segments are defined by a consensus sequence of 54 residues. Chicken alpha-spectrin (Wasenius, V.-M., M. Saraste, P. Salven, M. Eramaa, L. Holm, V.-P. Lehto. 1989. J. Cell Biol. 108:79-93) shares 50 of these consensus positions. Through comparison of spectrin and alpha-actinin sequences, we describe a second lineage of spectrin segments (20 and 21) that differs from the 106-residue segments by an 8-residue insertion and by lack of many of the consensus residues. We present a model of spectrin evolution in which the repetitive lineage of spectrin segments and the nonrepetitive lineage of segments found in spectrin and alpha-actinin arose by separate multiplication events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.