ArticleHippocampus2017
Disruption of amygdala-entorhinal-hippocampal network in late-life depression.
Article in Hippocampus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Depression and episodic memory across the adult lifespan: A meta-analytic review.Psychological bulletin · 2021Pooled it
- Alterations of structural-functional connectivity coupling in older adults with depressive symptoms.Psychological medicine · 2025Article
- Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice.Inflammation · 2025Article
- Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice.Biological psychiatry global open science · 2025Article
- Subclinical depressive symptoms and job stress differentially impact memory in working and retired older adults.Scientific reports · 2025Article
- High and low current perceived stress associated with enhanced emotional mnemonic discrimination.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Social cues tip the scales in emotional processing of complex pictures.Psychological research · 2024Article
- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.Advances in neurobiology · 2024Review
- Distinct neural activations correlate with maximization of reward magnitude versus frequency.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
- Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases.Translational neurodegeneration · 2023Article
- Differences in olfactory functional connectivity in early-onset depression and late-onset depression.Psychoradiology · 2023Article
- Perceived antidepressant efficacy associated with reduced negative and enhanced neutral mnemonic discrimination.Frontiers in human neuroscience · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- The Entorhinal Cortex and Adult Neurogenesis in Major Depression.International journal of molecular sciences · 2021Review
- Hippocampal PGC-1α-mediated positive effects on parvalbumin interneurons are required for the antidepressant effects of running exercise.Translational psychiatry · 2021Article
- Neural Circuitry-Neurogenesis Coupling Model of Depression.International journal of molecular sciences · 2021Review
- The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021Article
- Machine Learning Prediction of Treatment Outcome in Late-Life Depression.Frontiers in psychiatry · 2021Article
- Task MRI-Based Functional Brain Network of Major Depression.Advances in experimental medicine and biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-) depressive symptoms using high-resolution fMRI that is capable of discerning signals in hippocampal subfields and amygdala nuclei. Scanning was conducted during performance of an emotional discrimination task used previously to examine the relationship between depressive symptoms and amygdala-mediated emotional modulation of hippocampal pattern separation in young adults. We found that hippocampal dentate gyrus (DG)/CA3 activity was reduced during correct discrimination of negative stimuli and increased during correct discrimination of neutral items in DS+ compared to DS- adults. The extent of the latter increase was correlated with symptom severity. Furthermore, DG/CA3 and basolateral amygdala (BLA) activity predicted discrimination performance on negative trials, a relationship that depended on symptom severity. The impact of the BLA on depressive symptom severity was mediated by the DG/CA3 during discrimination of neutral items, and by the lateral entorhinal cortex (LEC) during false recognition of positive items. These results shed light on a novel mechanistic account for amygdala-hippocampal network changes and concurrent alterations in emotional episodic memory in LLD. The BLA-LEC-DG/CA3 network, which comprises a key pathway by which emotion modulates memory, is specifically implicated in LLD. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.