ArticleThe ISME journal2017
Divergent functional isoforms drive niche specialisation for nutrient acquisition and use in rumen microbiome.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 112 citations in OpenAlex.
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- Prebiotic Xylo-Oligosaccharides Modulate the Gut Microbiome to Improve Innate Immunity and Gut Barrier Function and Enhance Performance in Piglets Experiencing Post-Weaning Diarrhoea.Microorganisms · 2025Article
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- Host-Microbiota Interactions in the Pathogenesis of Porcine Fetal Mummification.Microorganisms · 2025Article
- Response of rumen methane production and microbial community to different abatement strategies in yaks.BMC microbiology · 2025Article
- Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens.Microbiome · 2025Article
- The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance.Microorganisms · 2025Article
- A metagenomic catalogue of the ruminant gut archaeome.Nature communications · 2024Article
- A compendium of ruminant gastrointestinal phage genomes revealed a higher proportion of lytic phages than in any other environments.Microbiome · 2024Article
- Diversity and host interaction of the gut microbiota in specific pathogen-free pigs.Frontiers in microbiology · 2024Article
- Studies on fatty acids and microbiota characterization of the gastrointestinal tract of Tianzhu white yaks.Frontiers in microbiology · 2024Article
- Effects of dietary energy levels on microorganisms and short-chain fatty acids of rumen and tight junction proteins in Honghe Yellow cattle.Frontiers in microbiology · 2024Article
- Colonization and development of the gut microbiome in calves.Journal of animal science and biotechnology · 2023Review
- Oral administration ofFrontiers in veterinary science · 2023Article
- Prevotella: A Key Player in Ruminal Metabolism.Microorganisms · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Many microbes in complex competitive environments share genes for acquiring and utilising nutrients, questioning whether niche specialisation exists and if so, how it is maintained. We investigated the genomic signatures of niche specialisation in the rumen microbiome, a highly competitive, anaerobic environment, with limited nutrient availability determined by the biomass consumed by the host. We generated individual metagenomic libraries from 14 cows fed an ad libitum diet of grass silage and calculated functional isoform diversity for each microbial gene identified. The animal replicates were used to calculate confidence intervals to test for differences in diversity of functional isoforms between microbes that may drive niche specialisation. We identified 153 genes with significant differences in functional isoform diversity between the two most abundant bacterial genera in the rumen (Prevotella and Clostridium). We found Prevotella possesses a more diverse range of isoforms capable of degrading hemicellulose, whereas Clostridium for cellulose. Furthermore, significant differences were observed in key metabolic processes indicating that isoform diversity plays an important role in maintaining their niche specialisation. The methods presented represent a novel approach for untangling complex interactions between microorganisms in natural environments and have resulted in an expanded catalogue of gene targets central to rumen cellulosic biomass degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.