Evidence map›Paper›PMID 28085062›Full record

ArticleMolecules (Basel, Switzerland)2017

Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro.

Zhengtu Li, Li Li, Hongxia Zhou, Lijuan Zeng, Tingting Chen, Qiaolian Chen, Beixian Zhou, Yutao Wang, Qiaoyan Chen, Ping Hu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
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  16. Immunomodulatory effects ofExperimental and therapeutic medicine · 2021
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  17. Review
  18. Article
  19. Development and Effects of Influenza Antiviral Drugs.Molecules (Basel, Switzerland) · 2021
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  20. Novel Fatty Acid inACS omega · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Zhengtu LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. tu276025@163.com.
Li LiThe First Hospital of Yulin, Yuxi Da Dao Road, Yulin 719000, China. shanxilili79@163.com.
Hongxia ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. zhouhongxia00307@163.com.
Lijuan ZengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. zwq.1988@163.com.
Tingting ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. lkting@126.com.
Qiaolian ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. qiangwei86@163.com.
Beixian ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. 13710749650@126.com.
Yutao WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. wang-yu-tao2008@163.com.
Qiaoyan ChenGuangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou University of Traditinal Chinese Medicine, Guangzhou 510180, China. christinecqy@163.com.
Ping HuShanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. huping@ecust.edu.cn.
Zifeng YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China. jeffyah@163.com.
First Affiliated Hospital of Guangzhou Medical University · CNEast China University of Science and Technology · CNMacau University of Science and Technology · MOYulin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza remains one of the major epidemic diseases worldwide, and rapid virus replication and collateral lung tissue damage caused by excessive pro-inflammatory host immune cell responses lead to high mortality rates. Thus, novel therapeutic agents that control influenza A virus (IAV) propagation and attenuate excessive pro-inflammatory responses are needed. Polysaccharide extract from

Indexed as

AnimalsAnti-Inflammatory AgentsAntiviral AgentsBronchiCell LineCell SurvivalChemokine CCL5Chemokine CXCL9ChickensDogsDrugs, Chinese HerbalEpithelial CellsGene Expression RegulationHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeAnti-Inflammatory AgentsAntiviral AgentsbanlangenCCL5 protein, humanChemokine CCL5Chemokine CXCL9CXCL9 protein, humanDrugs, Chinese HerbalIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6PolysaccharidesTLR3 protein, humanToll-Like Receptor 3anti-inflammatoryantiviralpolysaccharidesRadix isatidisTLR-3

Identifiers

PMID28085062
PMCPMC6155848
OpenAlexW2577234518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.