ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Crossed cerebellar diaschisis in acute ischemic stroke: Impact on morphologic and functional outcome.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Effectiveness of Electrical Stimulation on Upper Limb Function During the Acute Phase of Stroke: A Systematic Review and Meta-Analysis.Neurology international · 2026Review
- Deciphering Crossed Cerebellar Diaschisis in Patients with Large-Vessel Occlusion Acute Ischemic Stroke using BOLD Cerebrovascular Reactivity.Cerebellum (London, England) · 2026Article
- Infratentorial cerebral microbleeds and brain age gap in stroke patients: a cross-sectional neuroimaging study.GeroScience · 2026Article
- Crossed cerebellar diaschisis on CT perfusion in large vessel occlusion stroke: early predictors and clinical relevance in the hyperacute phase.Journal of neurology · 2026Article
- Prevalence and Imaging Correlates of Cerebral Diaschisis After Ischemic Stroke: A Systematic Review and Meta-Analysis.Brain sciences · 2025Review
- Disability and persistent motor deficits are linked to structural crossed cerebellar diaschisis in chronic stroke.Human brain mapping · 2023Article
- Long-Term Lower Limb Motor Function Correlates with Middle Cerebellar Peduncle Structural Integrity in Sub-Acute Stroke: A ROI-Based MRI Cohort Study.Brain sciences · 2023Article
- Crossed cerebellar diaschisis-related supratentorial hemodynamic and metabolic status measured by PET/MR in assessing postoperative prognosis in chronic ischemic cerebrovascular disease patients with bypass surgery.Annals of nuclear medicine · 2022Article
- Structural cerebellar reserve positively influences outcome after severe stroke.Brain communications · 2022Article
- Crossed Cerebellar Diaschisis Indicates Hemodynamic Compromise in Ischemic Stroke Patients.Translational stroke research · 2021Article
- Crossed Cerebellar Diaschisis in Patients with Diffuse Glioma Is Associated with Impaired Supratentorial Cerebrovascular Reactivity and Worse Clinical Outcome.Cerebellum (London, England) · 2020Article
- Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease.European journal of nuclear medicine and molecular imaging · 2020Article
- Characteristics of cerebral perfusion and diffusion associated with crossed cerebellar diaschisis after acute ischemic stroke.Japanese journal of radiology · 2020Article
- Diaschisis revisited: quantitative evaluation of thalamic hypoperfusion in anterior circulation stroke.NeuroImage. Clinical · 2020Article
- Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke.Journal of the American Heart Association · 2019Article
- Detection of Crossed Cerebellar Diaschisis by Intravoxel Incoherent Motion MR Imaging in Subacute Ischemic Stroke.Cell transplantation · 2019Article
- PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats.Contrast media & molecular imaging · 2018Article
- Functional recovery differences after stroke rehabilitation in patients with uni- or bilateral hemiparesis.Neurosciences (Riyadh, Saudi Arabia) · 2017Article
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12 authors at 3 institutions in 1 country.
Funding
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Abstract
Crossed cerebellar diaschisis (CCD) is the phenomenon of hypoperfusion and hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the related supratentorial region. Our aim was to analyze its influence on morphologic and functional outcome in acute ischemic stroke. Subjects with stroke caused by a large vessel occlusion of the anterior circulation were selected from an initial cohort of 1644 consecutive patients who underwent multiparametric CT including whole-brain CT perfusion. Two experienced readers evaluated the posterior fossa in terms of CCD absence (CCD-) or presence (CCD+). A total of 156 patients formed the study cohort with 102 patients (65.4%) categorized as CCD- and 54 (34.6%) as CCD+. In linear and logistic regression analyses, no significant association between CCD and final infarction volume (β = -0.440, p = 0.972), discharge mRS ≤ 2 (OR = 1.897, p = 0.320), or 90-day mRS ≤ 2 (OR = 0.531, p = 0.492) was detected. CCD+ patients had larger supratentorial cerebral blood flow deficits (median: 164 ml vs. 115 ml; p = 0.001) compared to CCD-patients. Regarding complications, CCD was associated with a higher rate of parenchymal hematomas (OR = 4.793, p = 0.035). In conclusion, CCD is frequently encountered in acute ischemic stroke caused by large vessel occlusion of the anterior circulation. CCD was associated with the occurrence of parenchymal hematoma in the ipsilateral cerebral infarction but did not prove to significantly influence patient outcome.
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