ArticleAlcoholism, clinical and experimental research2017
Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.
Article in Alcoholism, clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Recent breakthroughs in understanding the cerebellum's role in fetal alcohol spectrum disorder: A systematic review.Alcohol (Fayetteville, N.Y.) · 2024Pooled it
- Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.Neuroscience and biobehavioral reviews · 2022Pooled it
- Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure?Alcoholism, clinical and experimental research · 2018Pooled it
- Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report.Genes, brain, and behavior · 2025Article
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption.Biological psychiatry · 2020Article
- Maternal ethanol consumption before paternal fertilization: Stimulation of hypocretin neurogenesis and ethanol intake in zebrafish offspring.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Embryonic Ethanol Exposure Affects the Early Development, Migration, and Location of Hypocretin/Orexin Neurons in Zebrafish.Alcoholism, clinical and experimental research · 2019Article
- Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- DRD2 methylation and regional grey matter volumes in young adult offspring from families at ultra-high risk for alcohol dependence.Psychiatry research. Neuroimaging · 2019Article
- Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Substance use and mental health symptoms in adults with prenatal alcohol exposure.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOffspring with a family history of alcohol dependence (AD) have been shown to have altered structural and functional integrity of corticolimbic brain structures. Similarly, prenatal exposure to alcohol is associated with a variety of structural and functional brain changes. The goal of this study was to differentiate the brain gray matter volumetric differences associated with familial risk and prenatal exposure to alcohol among offspring while controlling for lifetime personal exposures to alcohol and drugs.
methodsA total of 52 high-risk (HR) offspring from maternal multiplex families with a high proportion of AD were studied along with 55 low-risk (LR) offspring. Voxel-based morphometric analysis was performed using statistical parametric mapping (SPM8) software using 3T structural images from these offspring to identify gray matter volume differences associated with familial risk and prenatal exposure.
resultsSignificant familial risk group differences were seen with HR males showing reduced volume of the left inferior temporal, left fusiform, and left and right insula regions relative to LR males, controlling for prenatal exposure to alcohol drugs and cigarettes. HR females showed a reduction in the right fusiform but also showed a reduction in volume in portions of the cerebellum (left crus I and left lobe 8). Prenatal alcohol exposure effects, assessed within the familial HR group, was associated with reduced right middle cingulum and left middle temporal volume. Even low exposure resulting from mothers drinking in amounts less than the median of those who drank (53 drinks or less over the course of the pregnancy) showed a reduction in volume in the right anterior cingulum and in the left cerebellum (lobes 4 and 5).
conclusionsFamilial risk for AD and prenatal exposure to alcohol and other drugs show independent effects on brain morphology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.