Evidence map›Paper›PMID 28084593›Full record

ArticleMolecular neurobiology2018

Pinocembrin Suppresses H

Marcos Roberto de Oliveira, Gustavo da Costa Ferreira, Flávia Bittencourt Brasil, Alessandra Peres

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  13. Review
  14. Article
  15. α-Cyperone Attenuates HFrontiers in pharmacology · 2020
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Marcos Roberto de OliveiraDepartment of Chemistry/ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, 78060-900, Brazil. mrobioq@gmail.com.
Gustavo da Costa FerreiraInstituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Flávia Bittencourt BrasilUniversidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
Alessandra PeresDepartamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Universidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal de Mato Grosso · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

CNPq Edital UniversalCNPq Produtividade em Pesquisa do CNPq - Nível 2CNPq UniversalFAPERJ Edital APQ1Fomento à Pesquisa FOPESQ/UFF
6 · The paper itself

Abstract

Mitochondria are susceptible to redox impairment, which has been associated with neurodegeneration. These organelles are both a source and target of reactive species. In that context, there is increasing interest in finding natural compounds that modulate mitochondrial function and mitochondria-related signaling in order to prevent or to treat diseases involving mitochondrial impairment. Herein, we investigated whether and how pinocembrin (PB) would prevent mitochondrial dysfunction elicited by the exposure of human neuroblastoma SH-SY5Y cells to hydrogen peroxide (H

Indexed as

AntioxidantsCell Line, TumorCell RespirationCell SurvivalFlavanonesHeme Oxygenase-1HumansHydrogen PeroxideMembrane Potential, MitochondrialMitochondriaNeuronsNF-E2-Related Factor 2Oxidation-ReductionOxidative StressReactive Oxygen SpeciesSignal TransductionAntioxidantsFlavanonesHeme Oxygenase-1Hydrogen PeroxideNFE2L2 protein, humanNF-E2-Related Factor 2pinocembrinReactive Oxygen SpeciesMitochondriaNF-κBNrf2PinocembrinRespiratory chainTricarboxylic aid cycle

Identifiers

PMID28084593
OpenAlexW2574255351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.