ArticleScientific reports2017
Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
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- Intraocular Lens Modifications for Postoperative Complication Prevention: Advances in Surface Engineering, Drug Delivery, and Photo-Responsive Strategies.Pharmaceutics · 2026Review
- Comparative biocompatibility of hydrophilic vs. hydrophobic intraocular lenses following phacoemulsification in patients with uveitis.PloS one · 2025Article
- Unanswered questions regarding the pathogenesis of late onset posterior capsular opacification.Frontiers in ophthalmology · 2025Review
- Efficacy evaluation and predictive value of IL-20 and Apelin-13 after cataract surgery by phacoemulsification combined with IOL implantation.Frontiers in medicine · 2025Article
- Innovative Polymeric Biomaterials for Intraocular Lenses in Cataract Surgery.Journal of functional biomaterials · 2024Review
- Utilization of a highly adaptable murine air pouch model for minimally invasive testing of the inflammatory potential of biomaterials.Frontiers in bioengineering and biotechnology · 2024Article
- Exploring anterion capsular contraction syndrome in cataract surgery: insights into pathogenesis, clinical course, influencing factors, and intervention approaches.Frontiers in medicine · 2024Review
- Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification.Pharmaceutics · 2022Review
- Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery.Frontiers in bioengineering and biotechnology · 2022Review
- Fouling in ocular devices: implications for drug delivery, bioactive surface immobilization, and biomaterial design.Drug delivery and translational research · 2021Review
- Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance.Pharmaceutics · 2021Article
- Therapeutic Ophthalmic Lenses: A Review.Pharmaceutics · 2020Review
- A Critical Appraisal of New Developments in Intraocular Lens Modifications and Drug Delivery Systems for the Prevention of Cataract Surgery Complications.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Micropatterned immobilization of membrane-mimicking polymer and peptides for regulation of cell behaviorsRSC advances · 2018Article
- Genetic variations in Bestrophin‑1 and associated clinical findings in two Chinese patients with juvenile‑onset and adult‑onset best vitelliform macular dystrophy.Molecular medicine reports · 2018Article
- Bestrophin 1 gene analysis and associated clinical findings in a Chinese patient with Best vitelliform macular dystrophy.Molecular medicine reports · 2017Article
- Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification.Cell death & disease · 2017Article
- Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells.Current molecular medicine · 2017Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocompatibility of intraocular lens (IOL) is critical to vision reconstruction after cataract surgery. Foldable hydrophobic acrylic IOL is vulnerable to the adhesion of extracellular matrix proteins and cells, leading to increased incidence of postoperative inflammation and capsule opacification. To increase IOL biocompatibility, we synthesized a hydrophilic copolymer P(MPC-MAA) and grafted the copolymer onto the surface of IOL through air plasma treatment. X-ray photoelectron spectroscopy, atomic force microscopy and static water contact angle were used to characterize chemical changes, topography and hydrophilicity of the IOL surface, respectively. Quartz crystal microbalance with dissipation (QCM-D) showed that P(MPC-MAA) modified IOLs were resistant to protein adsorption. Moreover, P(MPC-MAA) modification inhibited adhesion and proliferation of lens epithelial cells (LECs) in vitro. To analyze uveal and capsular biocompatibility in vivo, we implanted the P(MPC-MAA) modified IOLs into rabbits after phacoemulsification. P(MPC-MAA) modification significantly reduced postoperative inflammation and anterior capsule opacification (ACO), and did not affect posterior capsule opacification (PCO). Collectively, our study suggests that surface modification by P(MPC-MAA) can significantly improve uveal and capsular biocompatibility of hydrophobic acrylic IOL, which could potentially benefit patients with blood-aqueous barrier damage.
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