Evidence map›Paper›PMID 28084426›Full record

ArticleScientific reports2017

Multimodality MRI assessment of grey and white matter injury and blood-brain barrier disruption after intracerebral haemorrhage in mice.

Jie Yang, Qian Li, Zhongyu Wang, Cunfang Qi, Xiaoning Han, Xi Lan, Jieru Wan, Wenzhu Wang, Xiaochun Zhao, Zhipeng Hou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 99 citations in OpenAlex.

  1. Review
  2. S100A8 aggravates sepsis-associated encephalopathy by promoting PFKFB3-dependent glycolysis and microglial neuroinflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  7. Multimodal and serial MRI monitors brain peri-hematomal injury and repair mechanisms after experimental intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jie YangKey Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience, Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qian LiDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Zhongyu WangDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Cunfang QiDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Xiaoning HanDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Xi LanDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Jieru WanDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Wenzhu WangDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Xiaochun ZhaoDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Zhipeng HouDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Cong GaoKey Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience, Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
J Ricardo CarhuapomaDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Susumu MoriDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jiangyang ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Jian WangDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USGuangzhou Medical University · CNNew York University · US

Funding

Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
Continued Development and Maintenance of MriStudioR01NS084957 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MORI, SUSUMU · 2013 to 2022
$3.6M
Neuroprotective effect of flavanol (-) epicatechin after intracerebral hemorrhageR01AT007317 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$2.0M
PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhageR01NS078026 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$1.8M
NCCIH NIH HHS R01 AT007317NICHD NIH HHS R01 HD074593NINDS NIH HHS R01 NS078026NINDS NIH HHS R01 NS084957
6 · The paper itself

Abstract

In this study, we examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using a preclinical 11.7 Tesla MRI system. On T2-weighted MRI, lesion and striatal volumes were increased on day 3 and then decreased from days 7 to 28. On day 3, with an increase in striatal water content, vasogenic oedema in the perihaematomal region presented as increased T2 and increased apparent diffusion coefficient (ADC) signal. With a synchronous change in T2 and ADC signals, microglial activation peaked on day 3 in the same region and decreased over time. Iron deposition appeared on day 3 around the haematoma border but did not change synchronously with ADC signals. Vascular permeability measured by Evans blue extravasation on days 1, 3, and 7 correlated with the T1-gadolinium results, both of which peaked on day 3. On diffusion tensor imaging, white matter injury was prominent in the corpus callosum and internal capsule on day 3 and then partially recovered over time. Our results indicate that the evolution of grey/white matter injury and blood-brain barrier disruption after ICH can be assessed with multimodal MRI, and that perihaematomal vasogenic oedema might be attributable to microglial activation, iron deposition, and blood-brain barrier breakdown.

Indexed as

AnimalsBlood-Brain BarrierCerebral HemorrhageCorpus CallosumDiffusion Tensor ImagingDisease Models, AnimalGray MatterHumansMagnetic Resonance ImagingMiceMultimodal ImagingWhite Matter

Identifiers

PMID28084426
PMCPMC5234017
OpenAlexW2576998539

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.