ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2017
Male breast cancer precursor lesions: analysis of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
- Characterization of HER2 Expression Levels, Including HER2-Ultralow, in a Retrospective Male Breast Cancer Cohort.Life (Basel, Switzerland) · 2026Article
- Male ductal carcinoma in situ: diagnosis and management of a rare disease in men.BMJ case reports · 2024Article
- Clinicopathological analysis of 38 male patients diagnosed with breast cancer.Breast disease · 2024Article
- Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific Enhancers.International journal of molecular sciences · 2023Article
- Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?Current oncology (Toronto, Ont.) · 2022Review
- A Rare Case of Bilateral Synchronous Male Breast Cancer: A Multimodality Approach.European journal of breast health · 2022Article
- Male breast cancer: an update.Virchows Archiv : an international journal of pathology · 2022Review
- Male Breast Cancer: An Updated Review of Epidemiology, Clinicopathology, and Treatment.Journal of oncology · 2022Review
- Sex-Based Heterogeneity in the Clinicopathological Characteristics and Prognosis of Breast Cancer: A Population-Based Analysis.Frontiers in oncology · 2021Article
- Radiologic and Pathologic Findings of Atypical Ductal Hyperplasia in the Male Breast: Case Report and Literature Review.Taehan Yongsang Uihakhoe chi · 2020Article
- Loss of Y-Chromosome during Male Breast Carcinogenesis.Cancers · 2020Article
- Image-based screening for men at high risk for breast cancer: Benefits and drawbacks.Clinical imaging · 2020Review
- Pure Ductal Carcinoma in Situ in The Male Breast: A Rare Entity.European journal of breast health · 2020Article
- The molecular genetic make-up of male breast cancer.Endocrine-related cancer · 2019Article
- Male breast cancer: a disease distinct from female breast cancer.Breast cancer research and treatment · 2019Review
- Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study.World journal of surgical oncology · 2018Article
- X chromosome gain is related to increased androgen receptor expression in male breast cancer.Virchows Archiv : an international journal of pathology · 2018Article
- Preferential expression of NY-BR-1 and GATA-3 in male breast cancer.Journal of cancer research and clinical oncology · 2018Article
- Characterisation of male breast cancer: a descriptive biomarker study from a large patient series.Scientific reports · 2017Article
- Male Breast Cancer in the Age of Genetic Testing: An Opportunity for Early Detection, Tailored Therapy, and Surveillance.Radiographics : a review publication of the Radiological Society of North America, IncReview
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Authors and funding
16 authors at 10 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In men, data regarding breast cancer carcinogenesis are limited. The aim of our study was to describe the presence of precursor lesions adjacent to invasive male breast cancer, in order to increase our understanding of carcinogenesis in these patients. Central pathology review was performed for 1328 male breast cancer patients, registered in the retrospective joint analysis of the International Male Breast Cancer Program, which included the presence and type of breast cancer precursor lesions. In a subset, invasive breast cancer was compared with the adjacent precursor lesion by immunohistochemistry (n=83) or targeted next generation sequencing (n=7). Additionally, we correlated the presence of ductal carcinoma in situ with outcome. A substantial proportion (46.2%) of patients with invasive breast cancer also had an adjacent precursor lesion, mainly ductal carcinoma in situ (97.9%). The presence of lobular carcinoma in situ and columnar cell-like lesions were very low (<1%). In the subset of invasive breast cancer cases with adjacent ductal carcinoma in situ (n=83), a complete concordance was observed between the estrogen receptor, progesterone receptor, and HER2 status of both components. Next generation sequencing on a subset of cases with invasive breast cancer and adjacent ductal carcinoma in situ (n=4) showed identical genomic aberrations, including PIK3CA, GATA3, TP53, and MAP2K4 mutations. Next generation sequencing on a subset of cases with invasive breast cancer and an adjacent columnar cell-like lesion showed genomic concordance in two out of three patients. A multivariate Cox model for survival showed a trend that the presence of ductal carcinoma in situ was associated with a better overall survival, in particular in the Luminal B HER2+ subgroup. In conclusion, ductal carcinoma in situ is the most commonly observed precursor lesion in male breast cancer and its presence seems to be associated with a better outcome, in particular in Luminal B HER2+ cases. The rate of lobular carcinoma in situ and columnar cell-like lesions adjacent to male breast cancer is very low, but our findings support the role of columnar cell-like lesions as a precursor of male breast cancer.
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