ArticleNature communications2017
A minimal length rigid helical peptide motif allows rational design of modular surfactants.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels.Nature communications · 2026Article
- Assessment of the MARTINI 3 Performance for Short Peptide Self-Assembly.Journal of chemical theory and computation · 2024Article
- Design of stimuli-responsive minimalist heptad surfactants for stable emulsions.Communications materials · 2024Article
- Assembly of π-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework.Journal of the American Chemical Society · 2022Article
- Fundamentals and Design-Led Synthesis of Emulsion-Templated Porous Materials for Environmental Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Development of CHARMM Additive Potential Energy Parameters for α-Methyl Amino Acids.The journal of physical chemistry. B · 2021Article
- Review
- Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil-like fibers.Science advances · 2021Article
- Article
- Sequence-Dependent Nanofiber Structures of Phenylalanine and Isoleucine Tripeptides.International journal of molecular sciences · 2020Article
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
- Bacterial biopolymers: from pathogenesis to advanced materials.Nature reviews. Microbiology · 2020Review
- Functional Coiled-Coil-like Assembly by Knob-into-Hole Packing of Single Heptad Repeat.ACS nano · 2019Article
- Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres.Pharmaceutics · 2019Article
- Progress in synthesizing protocells.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Self-assembly of Functional Nanostructures by Short Helical Peptide Building Blocks.Protein and peptide letters · 2019Review
- Amphiphilic polypeptides with prolonged enzymatic stability for the preparation of self-assembled nanobiomaterials.RSC advances · 2018Article
- Reductionist Approach in Peptide-Based Nanotechnology.Annual review of biochemistry · 2018Review
- Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and Infections.Microbiology and molecular biology reviews : MMBR · 2018Review
- Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Extensive work has been invested in the design of bio-inspired peptide emulsifiers. Yet, none of the formulated surfactants were based on the utilization of the robust conformation and self-assembly tendencies presented by the hydrophobins, which exhibited highest surface activity among all known proteins. Here we show that a minimalist design scheme could be employed to fabricate rigid helical peptides to mimic the rigid conformation and the helical amphipathic organization. These designer building blocks, containing natural non-coded α-aminoisobutyric acid (Aib), form superhelical assemblies as confirmed by crystallography and microscopy. The peptide sequence is amenable to structural modularity and provides the highest stable emulsions reported so far for peptide and protein emulsifiers. Moreover, we establish the ability of short peptides to perform the dual functions of emulsifiers and thickeners, a feature that typically requires synergistic effects of surfactants and polysaccharides. This work provides a different paradigm for the molecular engineering of bioemulsifiers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.