A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver.

Janeli Viil, Mariliis Klaas, Kadri Valter, Denis Belitškin, Sten Ilmjärv, Viljar Jaks

Abstract read

In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Road to stemness in hepatocellular carcinoma.World journal of gastroenterology · 2017
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Janeli ViilInstitute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Mariliis KlaasInstitute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Kadri ValterInstitute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Denis BelitškinInstitute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Sten IlmjärvDepartment of Pathology and Immunology, Medical School, University of Geneva, Geneva, Switzerland.

Viljar JaksInstitute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells with slow proliferation kinetics that retain the nuclear label over long time periods-the label-retaining cells (LRCs)-represent multipotent stem cells in a number of adult tissues. Since the identity of liver LRCs (LLRCs) had remained elusive we utilized a genetic approach to reveal LLRCs in normal non-injured livers and characterized their regenerative properties in vivo and in culture. We found that LLRCs were located in biliary vessels and participated in the regeneration of biliary but not hepatocyte injury. In culture experiments the sorted LLRCs displayed an enhanced self-renewal capacity but a unipotent biliary differentiation potential. Transcriptome analysis revealed a unique set of tumorigenesis- and nervous system-related genes upregulated in LLRCs when compared to non-LRC cholangiocytes. We conclude that the LLRCs established during the normal morphogenesis of the liver do not represent a multipotent primitive somatic stem cell population but act as unipotent biliary progenitor cells.

Indexed as

AnimalsBile DuctsCell LineageCell MovementCell ProliferationCell TrackingEpithelial CellsGene Expression ProfilingHepatocytesLiverMiceMorphogenesisMultipotent Stem CellsRegeneration

Identifiers

PMID28084309

DOI10.1038/srep40322

PMCPMC5234023

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.