Evidence map›Paper›PMID 28084200›Full record

ReviewMicrobiology spectrum2016

Innate Immune Responses to Bladder Infection.

Byron W Hayes, Soman N Abraham

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Innate immunity · 2020
    Trial
  2. Article
  3. CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025
    Review
  4. Article
  5. Multiplexed PCR to measureApplied and environmental microbiology · 2025
    Article
  6. Article
  7. The immune mechanisms of the urinary tract against infections.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Byron W HayesDepartments of Pathology.
Soman N AbrahamDepartments of Pathology.
Duke Medical Center · US

Funding

Development of Efficacious and Stable Nasal Vaccine FormulationsU01AI082107 · NIAID · DUKE UNIVERSITY · PI STAATS, HERMAN F · 2009 to 2013
$3.8M
Overcoming Immunosenescence by Nanoparticle-Mediated ActivationR01AI096305 · NIAID · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N, LEONG, KAM W · 2012 to 2016
$1.8M
Mechanism of Bacterial Expulsion from Infected Bladder Cells.R56DK095198 · NIDDK · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2012 to 2012
$200k
NIAID NIH HHS R01 AI096305NIAID NIH HHS U01 AI082107NIDDK NIH HHS R56 DK095198
6 · The paper itself

Abstract

Urinary tract infections are one of the most frequent bacterial infections of mankind. In spite of this frequency, the study of the immune system in the urinary tract has not attracted much attention. This could, in part, be attributable to the widespread use of antibiotics and similar antimicrobial agents, which for many decades have been both highly effective and relatively inexpensive to administer. In light of the emergence of multidrug-resistant bacteria among urinary tract infection isolates, interest in understanding the immune system in the urinary tract has grown. Several recent studies have revealed the existence of a powerful and highly coordinated innate immune system in the urinary tract designed to rapidly clear infecting pathogens; however, it also evokes harmful side effects.

Indexed as

Immunity, InnateAnimalsBacterial InfectionsCystitisDisease Models, AnimalHumansUrinary Bladder

Identifiers

PMID28084200
PMCPMC5242417
OpenAlexW2599566629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.