Evidence map›Paper›PMID 28084189›Full record

ArticleJournal of the International Association of Providers of AIDS Care

Impact of Unplanned Care Interruption on CD4 Response Early After ART Initiation in a Nigerian Cohort.

Aimalohi A Ahonkhai, Juliet Adeola, Bolanle Banigbe, Ifeyinwa Onwuatuelo, Abdulkabir B Adegoke, Ingrid V Bassett, Elena Losina, Kenneth A Freedberg, Prosper Okonkwo, Susan Regan

Abstract read
In one paragraph

Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aimalohi A Ahonkhai1 Division of infectious Disease, Massachusetts General Hospital, Boston, MA, USA.
Juliet Adeola4 AIDS Prevention Initiative in Nigeria (APIN), Abuja, Nigeria.
Bolanle Banigbe4 AIDS Prevention Initiative in Nigeria (APIN), Abuja, Nigeria.
Ifeyinwa Onwuatuelo4 AIDS Prevention Initiative in Nigeria (APIN), Abuja, Nigeria.
Abdulkabir B Adegoke2 Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Ingrid V Bassett1 Division of infectious Disease, Massachusetts General Hospital, Boston, MA, USA.
Elena Losina2 Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Kenneth A Freedberg1 Division of infectious Disease, Massachusetts General Hospital, Boston, MA, USA.
Prosper Okonkwo3 Harvard Medical School, Boston, MA, USA.
Susan Regan2 Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
"Implementation of Programs for Prevention, Care and Treatment of HIV/AIDS in theU2GPS001058 · PS · AIDS PREVENTION INITIATIVE IN NIGERIA · PI OKONKWO, PROSPER IFEANACHO · 2008 to 2013
$83.4M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
Optimizing HIV Care in Less Developed CountriesR37AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FREEDBERG, KENNETH ALAN · 2018 to 2024
$6.6M
Linkage & Retention: A Randomized Trial to Optimize HIV/TB Care in South AfricaR01MH090326 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BASSETT, INGRID VALERIE · 2010 to 2014
$2.9M
Decreasing Interruptions and Losses from HIV Care in NigeriaK23AI106406 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AHONKHAI, AIMALOHI · 2013 to 2017
$914k
NCHHSTP CDC HHS U2G PS001058NIAID NIH HHS K23 AI106406NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI058736NIAID NIH HHS R37 AI058736NIMH NIH HHS R01 MH090326
6 · The paper itself

Abstract

The authors conducted a retrospective cohort study of unplanned care interruption (UCI) among adults initiating antiretroviral therapy (ART) from 2009 to 2011 in a Nigerian clinic. The authors used repeated measures regression to model the impact of UCI on CD4 count upon return to care and rate of CD4 change on ART. Among 2496 patients, 83% had 0, 15% had 1, and 2% had ≥2 UCIs. Mean baseline CD4 for those with 0, 1, or ≥2 UCIs was 228/cells/mm

Indexed as

Drug MonitoringAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountContinuity of Patient CareFemaleHIV InfectionsHumansMaleNigeriaRetrospective StudiesAnti-Retroviral Agentsadherencecare interruptionCD4HIV infectionimmunologic recovery

Identifiers

PMID28084189
PMCPMC5289066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.