ArticleAmerican journal of Alzheimer's disease and other dementias2017
Association of GWAS Top Genes With Late-Onset Alzheimer's Disease in Colombian Population.
Article in American journal of Alzheimer's disease and other dementias, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Systematic review and meta-analysis of the association betweenFrontiers in aging neuroscience · 2024Pooled it
- BIN1 rs744373 variant shows different association with Alzheimer's disease in Caucasian and Asian populations.BMC bioinformatics · 2019Pooled it
- Analyzing 74,248 Samples Confirms the Association Between CLU rs11136000 Polymorphism and Alzheimer's Disease in Caucasian But Not Chinese population.Scientific reports · 2018Pooled it
- HYPOTHESIS: Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer's disease in humans.Prostaglandins, leukotrienes, and essential fatty acids · 2025Article
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Heterogeneity in Alzheimer's Disease Diagnosis and Progression Rates: Implications for Therapeutic Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- ABCA7, a Genetic Risk Factor Associated with Alzheimer's Disease Risk in African Americans.Journal of Alzheimer's disease : JAD · 2022Review
- Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.Alzheimer's research & therapy · 2021Article
- GWAS-Top Polymorphisms Associated With Late-Onset Alzheimer Disease in Brazil: Pointing Out Possible New Culprits Among Non-Coding RNAs.Frontiers in molecular biosciences · 2021Article
- First Report of CR1 Polymorphisms and Soluble CR1 Levels Associated with Late Onset Alzheimer's Disease (LOAD) in Latin America.Journal of molecular neuroscience : MN · 2020Article
- Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer's Disease?Journal of molecular neuroscience : MN · 2020Article
- Genetic Variants ofFrontiers in neurology · 2019Article
- ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer's disease without dementia.Annals of translational medicine · 2018Article
- Impact of late-onset Alzheimer's genetic risk factors on beta-amyloid endocytic production.Cellular and molecular life sciences : CMLS · 2018Review
- Genome-wide significant risk factors on chromosome 19 and theOncotarget · 2018Article
- Regulation of the Late Onset alzheimer's Disease AssociatedAmerican journal of Alzheimer's disease and other dementiasArticle
- Genetics of dementia: insights from Latin America.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations.
methodsThe association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls from the Colombian population.
resultsIn a multivariate analysis using age, gender, APOE∊4 status, and admixture covariates, significant associations were obtained ( P < .05) for variants in BIN1 (rs744373, odds ratio [OR]: 1.42), CLU (rs11136000, OR: 0.66), PICALM (rs541458, OR: 0.69), ABCA7 (rs3764650, OR: 1.7), and CD33 (rs3865444, OR: 1.12). Likewise, a significant interaction effect was observed between CLU and CR1 variants with APOE.
conclusionThis study replicated the associations previously reported in populations of European ancestry and shows that APOE variants have a regulatory role on the effect that variants in other loci have on LOAD, reflecting the importance of gene-gene interactions in the etiology of neurodegenerative diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.