SynthesisJournal of diabetes investigation2017
Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis.
Synthesis in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis.Journal of diabetes investigation · 2017Pooled it
- Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.Obesity (Silver Spring, Md.) · 2026Trial
- Trial
- Weight dissatisfaction is linked to higher eating disinhibition and greater weight fluctuations in adults with weight management experience.Journal of health psychology · 2026Article
- Type 2 Diabetes Incidence and Mortality: Associations with Physical Activity, Fitness, Weight Loss, and Weight Cycling.Reviews in cardiovascular medicine · 2022Review
- Smoking Cessation, Weight Gain, and Risk for Type 2 Diabetes: A Prospective Study.International journal of public health · 2022Article
- Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study.Diabetes & metabolism journal · 2021Article
- The impact of early body-weight variability on long-term weight maintenance: exploratory results from the NoHoW weight-loss maintenance intervention.International journal of obesity (2005) · 2021Article
- Data Imputation and Body Weight Variability Calculation Using Linear and Nonlinear Methods in Data Collected From Digital Smart Scales: Simulation and Validation Study.JMIR mHealth and uHealth · 2020Article
- Intentional weight loss as a predictor of type 2 diabetes occurrence in a general adult population.BMJ open diabetes research & care · 2020Article
- Body weight variability is not associated with changes in risk factors for cardiometabolic disease.International Journal of Cardiology. Hypertension · 2020Article
- Weight cycling is associated with adverse cardiometabolic markers in a cross-sectional representative US sample.Journal of epidemiology and community health · 2020Article
- Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study.Journal of clinical medicine · 2019Article
- Validity of a triaxial accelerometer and simplified physical activity record in older adults aged 64-96 years: a doubly labeled water study.European journal of applied physiology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionThe present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies. MATERIALS AND
methodsAn electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method.
resultsEight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09).
conclusionsUnstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.