ArticleAging cell2017
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.
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Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.Cell death & disease · 2026Article
- Arginine Transporters in Human Cancers: Emerging Mechanisms and Clinical Implications.Biomolecules · 2026Review
- The blood-brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila.PLoS biology · 2025Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Article
- Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice.Aging cell · 2025Article
- Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy.Antioxidants (Basel, Switzerland) · 2025Review
- How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration.Experimental eye research · 2025Review
- G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development.PloS one · 2025Article
- Article
- Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.Nature metabolism · 2024Article
- The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.Nature communications · 2024Article
- Lysosomes in retinal health and disease.Trends in neurosciences · 2023Review
- A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes.Current biology : CB · 2023Article
- Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.Autophagy · 2023Article
- Article
- mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction forInternational journal of molecular sciences · 2021Article
- BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.Autophagy · 2021Article
- βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells.Communications biology · 2021Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Peng ShangDepartment of Ophthalmology of Shanghai Tenth People's Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China.
Mallika ValapalaThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rhonda GrebeThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stacey HoseThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sayan GhoshThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Imran A BhuttoThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James T HandaThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerard A LuttyThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lixia LuDepartment of Ophthalmology of Shanghai Tenth People's Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China.
Jun WanThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jiang QianThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuri SergeevNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Rosa PuertollanoCell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
J Samuel ZiglerThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Guo-Tong XuDepartment of Ophthalmology of Shanghai Tenth People's Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China.
Debasish SinhaThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USTongji University · CNNational Heart Lung and Blood Institute · USNational Institutes of Health · USShanghai Tenth People's Hospital · CN
Funding
Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1MProteins From Hereditary Eye Diseases: In-silico and Experimental StudiesZIAEY000476 · NEI · NATIONAL EYE INSTITUTE · PI SERGEEV, YURI · 2009 to 2025
$16.8MLysosome biogenesis and homeostasisZIAHL006151 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PUERTOLLANO, ROSA · 2012 to 2025
$15.0MRole of endolysosomal channels in calcium homeostasis and traffickingZIAHL006075 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PUERTOLLANO, ROSA · 2010 to 2025
$8.7MA novel bA3/A1-crystallin gene mutation results in persistent fetal vasculatureR01EY019037 · NEI · JOHNS HOPKINS UNIVERSITY · PI SINHA, DEBASISH · 2008 to 2015
$4.1MNrf2 signaling and oxidative stress in Age-related macular degenerationR01EY019904 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2010 to 2016
$4.1MNEI NIH HHS P30 EY001765NEI NIH HHS R01 EY019037NEI NIH HHS R01 EY019904
Abstract
The dry (nonneovascular) form of age-related macular degeneration (AMD), a leading cause of blindness in the elderly, has few, if any, treatment options at present. It is characterized by early accumulation of cellular waste products in the retinal pigmented epithelium (RPE); rejuvenating impaired lysosome function in RPE is a well-justified target for treatment. It is now clear that amino acids and vacuolar-type H
Indexed as
Signal TransductionAgingAmino AcidsAmino Acid Transport SystemsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsbeta-Crystallin A ChainCrystallinsCytosolEpithelial CellsGene Regulatory NetworksLysosomesMechanistic Target of Rapamycin Complex 1Mice, KnockoutMultiprotein ComplexesPhosphorylationAmino AcidsAmino Acid Transport SystemsBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsbeta-Crystallin A ChainCryba1 protein, mouseCrystallinsMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesPAT4 protein, mouseTcfeb protein, mouseTOR Serine-Threonine Kinasesage-related macular degenerationamino acid transporter (PAT4/SLC36A4)complex 1 (mTORC1)coordinated lysosomal expression and regulation (CLEAR) networklysosomes; mechanistic target of rapamycinmouse modelphotoreceptor degenerationretinal pigmented epithelium (RPE)signal transductiontranscription factors EB (TFEB) and E3 (TFE3)visual cycle proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.