Evidence map›Paper›PMID 28083884›Full record

ArticleThe European journal of neuroscience2017

Disabled-1 dorsal horn spinal cord neurons co-express Lmx1b and function in nociceptive circuits.

Griselda M Yvone, Hannah H Zhao-Fleming, Joe C Udeochu, Carmine L Chavez-Martinez, Austin Wang, Megumi Hirose-Ikeda, Patricia E Phelps

Open access · greenAbstract read
In one paragraph

Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Griselda M YvoneDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Hannah H Zhao-FlemingDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Joe C UdeochuDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Carmine L Chavez-MartinezDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Austin WangDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Megumi Hirose-IkedaDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.
Patricia E PhelpsDepartment of Integrative Biology and Physiology, UCLA, Terasaki Life Sciences Building, 610 Charles Young Dr. E, Los Angeles, CA, 90095-7239, USA.ORCID 0000-0003-0735-5341
Terasaki Foundation · US

Funding

Stem CellsP30HD004612 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 1985 to 2014
$19.5M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
PREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3M
NICHD NIH HHS P30 HD004612NICHD NIH HHS U54 HD087101NIGMS NIH HHS R25 GM055052NIGMS NIH HHS T32 GM008568
6 · The paper itself

Abstract

The Reelin-signaling pathway is essential for correct neuronal positioning within the central nervous system. Mutant mice with a deletion of Reelin, its lipoprotein receptors, or its intracellular adaptor protein Disabled-1 (Dab1), exhibit nociceptive abnormalities: thermal (heat) hyperalgesia and reduced mechanical sensitivity. To determine dorsal horn alterations associated with these nociceptive abnormalities, we first characterized the correctly positioned Dab1 neurons in wild-type and mispositioned neurons in Reelin-signaling pathway mutant lumbar spinal cord. Using immunofluorescence, we found that 70% of the numerous Dab1 neurons in Reln

Indexed as

NociceptionAnimalsCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsLIM-Homeodomain ProteinsMiceNerve Tissue ProteinsPosterior Horn CellsReelin ProteinSerine EndopeptidasesTranscription FactorsCell Adhesion Molecules, NeuronalDab1 protein, mouseExtracellular Matrix ProteinsLIM homeobox transcription factor 1 betaLIM-Homeodomain ProteinsNerve Tissue ProteinsReelin ProteinReln protein, mouseSerine EndopeptidasesTranscription Factorslateral cervical nucleuslateral spinal nucleusneuronal migration disorderspainReeler mouse

Identifiers

PMID28083884
PMCPMC5486991
OpenAlexW2574942315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.