Evidence map›Paper›PMID 28083818›Full record

ArticleMolecular neurobiology2018

Ferulic Acid Improves Cognitive Skills Through the Activation of the Heme Oxygenase System in the Rat.

Emanuela Mhillaj, Stefania Catino, Fiorella M Miceli, Rosaria Santangelo, Luigia Trabace, Vincenzo Cuomo, Cesare Mancuso

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In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Emanuela MhillajDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Stefania CatinoInstitute of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Fiorella M MiceliInstitute of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Rosaria SantangeloInstitute of Microbiology, Catholic University School of Medicine, Rome, Italy.
Luigia TrabaceDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Vincenzo CuomoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Cesare MancusoInstitute of Pharmacology, Catholic University School of Medicine, Rome, Italy. cesare.mancuso@unicatt.it.
Sapienza University of Rome · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last years, many studies reported on the antioxidant effects of ferulic acid (FA) in preclinical models of dementia through the activation of the heme oxygenase/biliverdin reductase (HO/BVR) system. However, only a few studies evaluated whether FA could improve neurological function under milder conditions, such as psychological stress. The aim of this study was to investigate the effects of FA (150 mg/kg intraperitoneal route) on cognitive function in male Wistar rats exposed to emotional arousal. Animals were randomly assigned to two experimental groups, namely not habituated or habituated to the experimental context, and the novel object recognition test was used to evaluate their cognitive performance. The administration of FA significantly increased long-term retention memory in not habituated rats. Ferulic acid increased the expression of HO-1 in the hippocampus and frontal cortex of not habituated rats only, whereas HO-2 resulted differently modulated in these cognitive brain areas. No significant effects on either HO-1 or HO-2 or BVR were observed in the cerebellum of both habituated and not habituated rats. Ferulic acid activated the stress axis in not habituated rats, as shown by the increase in hypothalamic corticotrophin-releasing hormone levels. Pre-treatment with Sn-protoporphyrin-IX [0.25 μmol/kg, intracerebroventricular route (i.c.v.)], a well-known inhibitor of HO activity through which carbon monoxide (CO) and biliverdin (BV) are generated, abolished the FA-induced improvement of cognitive performance only in not habituated rats, suggesting a role for HO-derived by-products. The CO-donor tricarbonyldichlororuthenium (II) (30 nmol/kg i.c.v.) mimicked the FA-related improvement of cognitive skills only in not habituated rats, whereas BV did not have any effect in any group. In conclusion, these results set the stage for subsequent studies on the neuropharmacological action of FA under conditions of psychological stress.

Indexed as

AnimalsCognitionCorticotropin-Releasing HormoneCoumaric AcidsFrontal LobeHeme Oxygenase (Decyclizing)HippocampusMaleMetalloporphyrinsOxidoreductases Acting on CH-CH Group DonorsProtoporphyrinsRatsRats, WistarRecognition, Psychologybiliverdin reductaseCorticotropin-Releasing HormoneCoumaric Acidsferulic acidHeme Oxygenase (Decyclizing)MetalloporphyrinsOxidoreductases Acting on CH-CH Group DonorsProtoporphyrinstin protoporphyrin IXBiliverdin reductaseEmotional arousalFerulic acidHeme oxygenaseRat brain

Identifiers

PMID28083818
OpenAlexW2572500700

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.