Evidence map›Paper›PMID 28083816›Full record

ArticleMolecular neurobiology2018

HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.

Yoon Lim, Linda Lin-Yan Wu, Si Chen, Ying Sun, Swarna Lekha Vijayaraj, Miao Yang, Larisa Bobrovskaya, Damien Keating, Xiao-Jiang Li, Xin-Fu Zhou

Abstract read
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
  6. Review
  7. Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  8. Disruption of axonal transport in neurodegeneration.The Journal of clinical investigation · 2023
    Review
  9. Selective motor activation in organelle transport along axons.Nature reviews. Molecular cell biology · 2022
    Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yoon LimSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.ORCID http://orcid.org/0000-0003-1110-1969
Linda Lin-Yan WuDepartment of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA, 5000, Australia.
Si ChenDepartment of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA, 5000, Australia.
Ying SunSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Swarna Lekha VijayarajDepartment of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA, 5000, Australia.
Miao YangSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Larisa BobrovskayaSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Damien KeatingDepartment of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA, 5000, Australia.
Xiao-Jiang LiDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Xin-Fu ZhouSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia. xin-fu.zhou@unisa.edu.au.
Flinders University · AUUniversity of South Australia · AUEmory University · US

Funding

Neuronal function of huntingtin-associated proteinR01NS036232 · NINDS · EMORY UNIVERSITY · PI ESCAYG, ANDREW P · 1998 to 2021
$6.7M
N-terminal huntingtin and Huntington disease neuropathologyR01NS101701 · NINDS · EMORY UNIVERSITY · PI ESCAYG, ANDREW P · 2017 to 2021
$2.2M
National Health and Medical Research Council 1017711National Health and Medical Research Council 480423NINDS NIH HHS R01 NS036232NINDS NIH HHS R01 NS101701
6 · The paper itself

Abstract

When BDNF binds to its receptors, TrkB and p75

Indexed as

AnimalsAnimals, NewbornBrain-Derived Neurotrophic FactorCells, CulturedEndocytosisHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNerve Tissue ProteinsNeuronsReceptor, trkBSignal TransductionBrain-Derived Neurotrophic FactorHap1 protein, mouseNerve Tissue ProteinsReceptor, trkBBDNFEndocytosisHAP1P75NTRProliferationTrkB

Identifiers

PMID28083816
PMCPMC5821608
OpenAlexW2575543841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.