ArticleJournal of the American Society for Mass Spectrometry2017
Spontaneous Mass and Charge Losses from Single Multi-Megadalton Ions Studied by Charge Detection Mass Spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Dual Apodization Maximizes Charge Resolution and Frequency Precision in Charge Detection Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- Spontaneous Fission of Charged Water Nanodrops: Unveiling the Stochastic Nature of Fission Pathways and Dynamics.Journal of the American Chemical Society · 2025Article
- Prolonged Trapping of Adeno-Associated Virus Capsids Reveals that Genome Packaging Affects Single-Ion Mass Spectrometry Measurements.Journal of the American Chemical Society · 2025Article
- Single-Ion Mass Spectrometry for Heterogeneous and High Molecular Weight Samples.Journal of the American Chemical Society · 2024Review
- Ion emission from 1-10 MDa salt clusters: individual charge state resolution with charge detection mass spectrometry.The Analyst · 2024Article
- Dynamics of Rayleigh Fission Processes in ∼100 nm Charged Aqueous Nanodrops.ACS central science · 2023Article
- Electrostatic Linear Ion Trap Optimization Strategy for High Resolution Charge Detection Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2023Article
- Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2022Article
- Applications of Charge Detection Mass Spectrometry in Molecular Biology and Biotechnology.Chemical reviews · 2022Review
- Direct observation of ion emission from charged aqueous nanodrops: effects on gaseous macromolecular charging.Chemical science · 2021Article
- Higher Resolution Charge Detection Mass Spectrometry.Analytical chemistry · 2020Article
- Enhanced Multiplexing in Fourier Transform Charge Detection Mass Spectrometry by Decoupling Ion Frequency from Mass to Charge Ratio.Journal of the American Society for Mass Spectrometry · 2019Article
- Dramatic Improvement in Sensitivity with Pulsed Mode Charge Detection Mass Spectrometry.Analytical chemistry · 2019Article
- Effects of Individual Ion Energies on Charge Measurements in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS).Journal of the American Society for Mass Spectrometry · 2019Article
- Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS).Journal of the American Society for Mass Spectrometry · 2018Article
- Determination of Collision Cross Sections Using a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2018Article
- Mass, mobility and MSThe Analyst · 2017Article
- Mass and Charge Measurements on Heavy Ions.Mass spectrometry (Tokyo, Japan) · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous mass and charge losses from individual multi-megadalton ions have been observed with charge detection mass spectrometry (CDMS) by trapping single hepatitis B virus (HBV) capsids for 3 s. Gradual increases in the oscillation frequency of single ions in the ion trap are attributed mainly to mass loss (probably solvent, water, and/or salt). The total mass lost during the 3 s trapping period peaks at around 20 kDa for 4 MDa HBV T = 4 capsids. Discrete frequency drops punctuate the gradual increases in the oscillation frequencies. The drops are attributed to a sudden loss of charge. In most cases a single positive charge is lost along with some mass (on average around 1000 Da). Charge loss occurs for over 40% of the trapped ions. It usually occurs near the beginning of the trapping event, and it occurs preferentially in regions of the trap with strong electric fields, indicating that external electric fields promote charge loss. This process may contribute to the decrease in m/z resolution that often occurs with megadalton ions. Graphical Abstract ᅟ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.