ArticleInternational orthopaedics2017
Role of platelet gel embedded within gelatin scaffold on healing of experimentally induced critical-sized radial bone defects in rats.
Article in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Platelet derivatives in oral and maxillofacial surgery: classification, and clinical applications.Frontiers in cell and developmental biology · 2026Review
- Surgical induction model of femoral defect in Wistar rats for bone repair histology.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Novel Techniques and Future Perspective for Investigating Critical-Size Bone Defects.Bioengineering (Basel, Switzerland) · 2022Review
- Effects of Combination of BMP7, PFG, and Autograft on Healing of the Experimental Critical Radial Bone Defect by Induced Membrane (Masquelet) Technique in Rabbit.The archives of bone and joint surgery · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the role of human platelet gel (PG) embedded within gelatin (Gel) scaffold on healing of critical-sized radial bone defects in rats.
methodsTwenty-five Sprague-Dawley rats were randomly divided into five equal groups. In each animal, critical-sized 5-mm bone defects were created in the radial bones of both forelimbs (n = 10/group). The defects were then either left untreated or filled with autograft, Gel, PG or Gel-PG. Before euthanasia, the healing defects were evaluated radiologically and clinically. The animals were euthanized after eight weeks and their radial bones evaluated by radiography, computed tomography (CT) scan, histology, biomechanical testing and ultrastructural evaluations.
resultsPG implantation significantly increased cellular differentiation, osteoblastic proliferation and consequently new bone formation so that those defects treated with PG showed superior structural and biomechanical properties to the Gel and PG-Gel-treated defects. The PG-treated defects had radiological, morphological and mechanical properties closely comparable with those of the autograft group. In contrast, in the PG-Gel group, Gel significantly reduced the beneficial effects of PG on bone healing.
conclusionsHuman PG had beneficial effects on bone regeneration, while combination of PG and Gel had no remarkable beneficial effect. Therefore, PG when used alone can be regarded as a promising osteoinductive and osteoconductive option in bone tissue engineering applications.
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