Evidence map›Paper›PMID 28083445›Full record

ArticleTranslational vision science & technology2017

Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery.

Fabiana Kashiwabuchi, Kunal S Parikh, Revaz Omiadze, Shuming Zhang, Lixia Luo, Himatkumar V Patel, Qingguo Xu, Laura M Ensign, Hai-Quan Mao, Justin Hanes and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Nanofiber-coated, tacrolimus-eluting sutures inhibit post-operative neointimal hyperplasia in rats.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Copper-Eluting Fibers for Enhanced Tissue Sealing and Repair.ACS applied materials & interfaces · 2020
    Article
  13. Article
  14. Development of banana (RSC advances · 2018
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fabiana KashiwabuchiDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kunal S ParikhCenter for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Revaz OmiadzeDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shuming ZhangDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.
Lixia LuoDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Himatkumar V PatelDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Qingguo XuDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laura M EnsignDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.
Justin HanesDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA ; Departments of Environmental Health Sciences, Oncology, Neurosurgery, and Pharmacology & Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter J McDonnellDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop and evaluate an antibiotic-eluting suture for ophthalmic surgery.

methodsWet electrospinning was used to manufacture sutures composed of poly(L-lactide), polyethylene glycol (PEG), and levofloxacin. Size, morphology, and mechanical strength were evaluated via scanning electron microscopy and tensile strength, respectively. In vitro drug release was quantified using high performance liquid chromatography. In vitro suture activity against Staphylococcus epidermidis was investigated through bacterial inhibition studies. Biocompatibility was determined via histological analysis of tissue sections surrounding sutures implanted into Sprague-Dawley rat corneas.

resultsSutures manufactured via wet electrospinning were 45.1 ± 7.7 μm in diameter and 0.099 ± 0.007 newtons (N) in breaking strength. The antibiotic release profile demonstrated a burst followed by sustained release for greater than 60 days. Increasing PEG in the polymer formulation, from 1% to 4% by weight, improved drug release without negatively affecting tensile strength. Sutures maintained a bacterial zone of inhibition for at least 1 week in vitro and elicited an in vivo tissue reaction comparable to a nylon suture.

conclusionsThere is a need for local, postoperative delivery of antibiotics following ophthalmic procedures. Wet electrospinning provides a suitable platform for the development of sutures that meet size requirements for ophthalmic surgery and are capable of sustained drug release; however, tensile strength must be improved prior to clinical use. TRANSLATIONAL RELEVANCE: No antibiotic-eluting suture exists for ophthalmic surgery. A biocompatible, high strength suture capable of sustained antibiotic release could prevent ocular infection and preclude compliance issues with topical eye drops.

Indexed as

biodegradabledrug deliverylevofloxacinmedical deviceocular

Identifiers

PMID28083445
PMCPMC5225995
OpenAlexW2587318307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.