Evidence map›Paper›PMID 28083057›Full record

ArticlePakistan journal of medical sciences

Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus.

Rabia Arshad, Muhammad Adnan Kanpurwala, Nasim Karim, Jahan Ara Hassan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Pooled it
  3. Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018
    Trial
  4. Article
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Interaction between Metformin, Folate and Vitamin BInternational journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Rabia ArshadDr. Rabia Arshad, MBBS, M. Phil. Assistant Professor and Head of Pharmacology Department, Altamash Institute of Dental Medicine, 2-R Sunset Boulevard, DHA, Karachi, Pakistan.
Muhammad Adnan KanpurwalaDr. Muhammad Adnan Kanpurwala, MBBS, M. Phil. Associate Professor, Physiology Department, Karachi Institute of Medical Sciences, Karachi, Pakistan.
Nasim KarimDr. Nasim Karim, MBBS, M. Phil, Ph D, Post Doc. Professor and Head of Pharmacology Department, Bahria University Medical and Dental College, Karachi, Pakistan.
Jahan Ara HassanDr. Jahan Ara Hasan, MBBS, FCPS, MCPS. Associate Professor, Gynecology and Obstetrics Department, Dow University of Health Sciences, Karachi, Pakistan.
Karachi Medical and Dental College · PKBahria University · PKDow University of Health Sciences · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM).

methodsAfter written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology.

resultsHeavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant.

conclusionMetformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group.

Indexed as

DietExerciseGestational diabetesGross morphologyMetforminMicroscopic morphologyPlacenta

Identifiers

PMID28083057
PMCPMC5216313
OpenAlexW2566307311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.