Evidence map›Paper›PMID 28082972›Full record

ArticleFrontiers in microbiology2016

Bovine Adenovirus-3 pVIII Suppresses Cap-Dependent mRNA Translation Possibly by Interfering with the Recruitment of DDX3 and Translation Initiation Factors to the mRNA Cap.

Lisanework E Ayalew, Amrutlal K Patel, Amit Gaba, Azharul Islam, Suresh K Tikoo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Dual biocontrol strategy: Fluorescent pseudomonads and methylotrophic bacteria in combating Corynespora leaf spot in blackgram.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The human DEAD-box helicase DDX3X as a regulator of mRNA translation.Frontiers in cell and developmental biology · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisanework E AyalewVaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SKCanada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SKCanada.
Amrutlal K PatelVaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SKCanada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SKCanada.
Amit GabaVaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SKCanada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SKCanada.
Azharul IslamVaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SK Canada.
Suresh K TikooVaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SKCanada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SKCanada; Vaccinology & Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, SKCanada.
University of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier, targeting of DDX3 by few viral proteins has defined its role in mRNA transport and induction of interferon production. This study was conducted to investigate the function of bovine adenovirus (BAdV)-3 pVIII during virus infection. Here, we provided evidence regarding involvement of DDX3 in cap dependent cellular mRNA translation and demonstrated that targeting of DDX3 by adenovirus protein VIII interfered with cap-dependent mRNA translation function of DDX3 in virus infected cells. Adenovirus late protein pVIII interacted with DDX3 in transfected and BAdV-3 infected cells. pVIII inhibited capped mRNA translation

Indexed as

BAdV-3cap-dependent mRNA translationDDX3pVIII

Identifiers

PMID28082972
PMCPMC5186766
OpenAlexW2564180285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.