Evidence map›Paper›PMID 28082894›Full record

ArticleFrontiers in aging neuroscience2016

Aerobic Activity in the Healthy Elderly Is Associated with Larger Plasticity in Memory Related Brain Structures and Lower Systemic Inflammation.

Jan-Willem Thielen, Christian Kärgel, Bernhard W Müller, Ina Rasche, Just Genius, Boudewijn Bus, Stefan Maderwald, David G Norris, Jens Wiltfang, Indira Tendolkar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Jan-Willem ThielenDonders Institute for Brain, Cognition and Behaviour, Radboud University NijmegenNijmegen, Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Essen-DuisburgEssen, Germany.
Christian KärgelDivision of Forensic Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL-University Hospital Bochum Bochum, Germany.
Bernhard W MüllerDepartment for Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-EssenEssen, Germany; Department of Psychology, University of WuppertalWuppertal, Germany.
Ina RascheDepartment for Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen Essen, Germany.
Just GeniusDonders Institute for Brain, Cognition and Behaviour, Radboud University NijmegenNijmegen, Netherlands; AbbVie Neuroscience DevelopmentLudwigshafen, Germany.
Boudewijn BusDepartment of Psychiatry, Radboud University Nijmegen Medical Center Nijmegen, Netherlands.
Stefan MaderwaldErwin L. Hahn Institute for Magnetic Resonance Imaging, University of Essen-Duisburg Essen, Germany.
David G NorrisDonders Institute for Brain, Cognition and Behaviour, Radboud University NijmegenNijmegen, Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Essen-DuisburgEssen, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen Göttingen, Germany.
Indira TendolkarDonders Institute for Brain, Cognition and Behaviour, Radboud University NijmegenNijmegen, Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Essen-DuisburgEssen, Germany; Department for Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-EssenEssen, Germany; Department of Psychiatry, Radboud University Nijmegen Medical CenterNijmegen, Netherlands.
Erwin L. Hahn Institute for Magnetic Resonance Imaging · DEUniversity of Duisburg-Essen · DEAbbVie (Germany) · DELWL-Universitätsklinikum Bochum · DERadboud University Nijmegen · NLUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive abilities decline over the time course of our life, a process, which may be mediated by brain atrophy and enhanced inflammatory processes. Lifestyle factors, such as regular physical activities have been shown to counteract those noxious processes and are assumed to delay or possibly even prevent pathological states, such as dementing disorders. Whereas the impact of lifestyle and immunological factors and their interactions on cognitive aging have been frequently studied, their effects on neural parameters as brain activation and functional connectivity are less well studied. Therefore, we investigated 32 healthy elderly individuals (60.4 ± 5.0

Indexed as

elderlyfMRIfunctional connectivityinflammationinterleukin-6memoryphysical activity

Identifiers

PMID28082894
PMCPMC5183624
OpenAlexW2561995913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.