Evidence map›Paper›PMID 28082458›Full record

ArticleDiabetes2017

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes.

Tony Jourdan, Gergő Szanda, Resat Cinar, Grzegorz Godlewski, David J Holovac, Joshua K Park, Sarah Nicoloro, Yuefei Shen, Jie Liu, Avi Z Rosenberg and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. The Neuroimmunology of Chronic Pain: From Rodents to Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  8. Article
  9. Review
  10. Peripheral Hybrid CBFrontiers in endocrinology · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Endocannabinoids in the Islets of Langerhans: the ugly, the bad, and the good facts.American journal of physiology. Endocrinology and metabolism · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Tony JourdanLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD tony.jourdan@nih.gov george.kunos@nih.gov.
Gergő SzandaLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Resat CinarLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Grzegorz GodlewskiLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
David J HolovacLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Joshua K ParkLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Sarah NicoloroProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
Yuefei ShenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
Jie LiuLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Avi Z RosenbergDivision of Renal Pathology, Department of Pathology, Johns Hopkins University, Baltimore, MD.
Ziyi LiuLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Michael P CzechProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD tony.jourdan@nih.gov george.kunos@nih.gov.
National Institute on Alcohol Abuse and Alcoholism · USNational Institutes of Health · USUniversity of Massachusetts Chan Medical School · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Endocannabinoids And Energy HomeostasisZIAAA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2009 to 2025
$28.4M
Paracrine Signaling by Kupffer Cells in Hepatic Insulin ResistanceR01DK103047 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 2015 to 2023
$5.0M
NIDDK NIH HHS R01 DK103047
6 · The paper itself

Abstract

Islet inflammation promotes β-cell loss and type 2 diabetes (T2D), a process replicated in Zucker Diabetic Fatty (ZDF) rats in which β-cell loss has been linked to cannabinoid-1 receptor (CB

Indexed as

AnimalsChemokine CCL2Diabetes Mellitus, Type 2Diabetic NephropathiesGene Knockout TechniquesHyperglycemiaInsulin-Secreting CellsInterferon Regulatory FactorsInterleukin-1betaIslets of LangerhansMacrophagesMaleRatsRats, ZuckerReceptor, Cannabinoid, CB1Signal TransductionCcl2 protein, ratChemokine CCL2IL1B protein, ratInterferon Regulatory FactorsInterleukin-1betaIRF5 protein, ratReceptor, Cannabinoid, CB1Tumor Necrosis Factor-alpha

Identifiers

PMID28082458
PMCPMC5360301
OpenAlexW2576890041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.