Evidence map›Paper›PMID 28082431›Full record

ArticlePhysiological reports2017

Underlying mechanism of the cyclic migrating motor complex in Suncus murinus: a change in gastrointestinal pH is the key regulator.

Anupom Mondal, Kouhei Koyama, Takashi Mikami, Taichi Horita, Shota Takemi, Sachiko Tsuda, Ichiro Sakata, Takafumi Sakai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Motilin stimulates food intake linked to gastric motility inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Advances in the physiology of gastric emptying.Neurogastroenterology and motility · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anupom MondalDepartment of Life Nano-Bio, Strategic Research Division, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Kouhei KoyamaArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Takashi MikamiArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Taichi HoritaArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Shota TakemiArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Sachiko TsudaArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Ichiro SakataArea of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Takafumi SakaiDepartment of Life Nano-Bio, Strategic Research Division, Graduate School of Science and Engineering, Saitama University, Saitama, Japan tsakai@mail.saitama-u.ac.jp.
Saitama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the fasted gastrointestinal (GI) tract, a characteristic cyclical rhythmic migrating motor complex (MMC) occurs in an ultradian rhythm, at 90-120 min time intervals, in many species. However, the underlying mechanism directing this ultradian rhythmic MMC pattern is yet to be completely elucidated. Therefore, this study aimed to identify the possible causes or factors that involve in the occurrence of the fasting gastric contractions by using Suncus murinus a small model animal featuring almost the same rhythmic MMC as that found in humans and dogs. We observed that either intraduodenal infusion of saline at pH 8 evoked the strong gastric contraction or continuously lowering duodenal pH to 3-evoked gastric phase II-like and phase III-like contractions, and both strong contractions were essentially abolished by the intravenous administration of MA 2029 (motilin receptor antagonist) and D-Lys3-GHRP6 (ghrelin receptor antagonist) in a vagus-independent manner. Moreover, we observed that the prostaglandin E2-alpha (PGE2

Indexed as

AcetamidesAdministration, IntravenousAnimalsDinoprostoneDuodenumFastingFemaleGastrointestinal MotilityHydrogen-Ion ConcentrationIminesMaleMotilinMyoelectric Complex, MigratingOligopeptidesReceptors, Gastrointestinal HormoneReceptors, NeuropeptideAcetamidesDinoprostonegrowth hormone releasing hexapeptideIminesMA 20565Motilinmotilin receptorOligopeptidesReceptors, Gastrointestinal HormoneReceptors, NeuropeptideGastrointestinal pHMMCmotilin

Identifiers

PMID28082431
PMCPMC5256163
OpenAlexW2577134455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.