ArticleScience (New York, N.Y.)2017
Deficiency of microRNA
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 159 citations in OpenAlex.
- High-throughput functional characterization of enhancers in totipotent-like cells.Nature communications · 2026Article
- Mechanisms coordinating exit from the stem cell state in mammals.Genes & development · 2026Review
- TBP regulates transposable element expression in early mouse embryos.The EMBO journal · 2026Article
- miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.Science advances · 2026Article
- Exit from totipotency in mammals: an epigenetic perspective.Frontiers in cell and developmental biology · 2026Review
- CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death.Science advances · 2025Article
- The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell.Cell regeneration (London, England) · 2025Article
- Ints7 deficiency activates DNA damage response to elicit resurgence of endogenous retrovirus MERVL and anastasis of embryonic stem cells.Nucleic acids research · 2025Article
- The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation.Genes & development · 2025Article
- Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos.Molecular medicine (Cambridge, Mass.) · 2025Article
- BMP and NODAL paracrine signalling regulate the totipotent-like cell state in embryonic stem cells.Frontiers in cell and developmental biology · 2025Article
- Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.Cell · 2024Article
- Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors.Nature biomedical engineering · 2024Article
- Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications.Signal transduction and targeted therapy · 2024Review
- Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion.Stem cell research & therapy · 2024Article
- Manipulating cell fate through reprogramming: approaches and applications.Development (Cambridge, England) · 2024Review
- How MicroRNAs Command the Battle against Cancer.International journal of molecular sciences · 2024Review
- Oviductal extracellular vesicles miRNA cargo varies in response to embryos and their quality.BMC genomics · 2024Article
- Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos.Journal of molecular cell biology · 2024Review
- Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells.Frontiers in cell and developmental biology · 2024Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 3 countries.
Yong Jin ChoiDivision of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA.ORCID 0000-0002-8830-3086
Chao-Po LinDivision of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA. lhe@berkeley.edu newcplin@gmail.com.ORCID 0000-0002-1457-1635
Davide RissoDivision of Biostatistics, School of Public Health, University of California, Berkeley, CA 94720, USA.ORCID 0000-0001-8508-5012
Sean ChenDivision of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA.ORCID 0000-0001-8343-0302
Thomas Aquinas KimDivision of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA.
Meng How TanDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Jin Billy LiDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Yalei WuThermo Fisher Scientific, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA.
Caifu ChenIntegrated DNA Technologies, 200 Chesapeake Drive, Redwood City, CA 94063, USA.
Zhenyu XuanDepartment of Molecular and Cell Biology, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0001-9344-8493
Todd MacfarlanEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.ORCID 0000-0003-2495-9809
Weiqun PengDepartment of Physics, George Washington University, Washington, DC 20052, USA.
K C Kent LloydMouse Biology Program, University of California, Davis, CA 95616, USA.ORCID 0000-0002-5318-4144
Sang Yong KimDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Terence P SpeedDepartment of Statistics, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-5403-7998
Lin HeDivision of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA. lhe@berkeley.edu newcplin@gmail.com.ORCID 0000-0001-5928-1263
Institut de Biologie Moléculaire et Cellulaire · FRStanford University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USGeorge Washington University · USIntegrated DNA Technologies (United States) · USNew York University · USThermo Fisher Scientific (United States) · USThe University of Melbourne · AUThe University of Texas at Dallas · USUniversity of California, Berkeley · USUniversity of California, Davis · US
Funding
KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7MUCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2MMechanisms of Mammalian Epigenome ReprogrammingZIAHD008933 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MACFARLAN, TODD SCOTT · 2013 to 2025
$19.1MClassification of Cortical Neurons by Single Cell TranscriptomicsU01MH105979 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2014 to 2016
$4.5MmiR-200 miRNAs repress tumor metastasis in lung adenocarcinomaR01CA139067 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2009 to 2021
$3.3MCharacterize the role of miR-34/449 miRNAs in regulating motile ciliogenesisR01GM114414 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2015 to 2018
$1.2MGenome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623kIllumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500kNCI NIH HHS R01 CA139067NCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NIGMS NIH HHS R01 GM114414NIH HHS U42 OD012210NIH HHS UM1 OD023221NIMH NIH HHS U01 MH105979
Abstract
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) efficiently generate all embryonic cell lineages but rarely generate extraembryonic cell types. We found that microRNA
Indexed as
AnimalsCell DifferentiationCell LineageCells, CulturedEmbryonic Stem CellsEndogenous RetrovirusesFemaleGATA2 Transcription FactorGene Expression RegulationGene Knockdown TechniquesInduced Pluripotent Stem CellsMaleMetabolic Networks and PathwaysMiceMice, Inbred C57BLMicroRNAsGata2 protein, mouseGATA2 Transcription FactorMicroRNAsMIRN34a microRNA, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.