Evidence map›Paper›PMID 28082324›Full record

ArticleG3 (Bethesda, Md.)2017

Genetic Dissection of a QTL Affecting Bone Geometry.

Olivia L Sabik, Juan F Medrano, Charles R Farber

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Olivia L SabikCenter for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0003-2334-5936
Juan F MedranoDepartment of Animal Science, University of California, Davis, California 95616.ORCID 0000-0001-7113-3183
Charles R FarberCenter for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908 crf2s@virginia.edu.ORCID 0000-0002-6748-4711

Funding

TRAINING IN CELL AND MOLECULAR BIOLOGYT32GM008136 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STUKENBERG, P. TODD · 1985 to 2020
$8.5M
Genetic analysis of bone strengthR01AR068345 · NIAMS · UNIVERSITY OF VIRGINIA · PI FARBER, CHARLES R, HOROWITZ, MARK C · 2016 to 2020
$3.1M
Systems Genetics of Osteoblast ActivityR01AR064790 · NIAMS · UNIVERSITY OF VIRGINIA · PI ACKERT-BICKNELL, CHERYL LYNNE, FARBER, CHARLES R · 2015 to 2019
$2.0M
Discovery of Bone Formation Genes through Integrative GenomicsR01AR057759 · NIAMS · UNIVERSITY OF VIRGINIA · PI FARBER, CHARLES R · 2011 to 2015
$1.7M
Positional cloning of obesity genes from congenic miceR01DK069978 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WARDEN, CRAIG H · 2006 to 2010
$1.7M
CHARACTERIZATION OF A MAJOR OBESITY LOCUSF32DK074317 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FARBER, CHARLES R · 2006 to 2008
$116k
NIAMS NIH HHS R01 AR057759NIAMS NIH HHS R01 AR064790NIAMS NIH HHS R01 AR068345NIDDK NIH HHS F32 DK074317NIDDK NIH HHS R01 DK069978NIGMS NIH HHS T32 GM008136
6 · The paper itself

Abstract

Parameters of bone geometry such as width, length, and cross-sectional area are major determinants of bone strength. Although these traits are highly heritable, few genes influencing bone geometry have been identified. Here, we dissect a major quantitative trait locus (QTL) influencing femur size. This QTL was originally identified in an F2 cross between the C57BL/6J-hg/hg (HG) and CAST/EiJ strains and was referred to as femur length in high growth mice 2 (

Indexed as

AllelesAnimalsBody HeightChromosome MappingFemaleFemurGene Expression RegulationGenome-Wide Association StudyHumansLod ScoreMaleMice, Inbred C57BLOrgan SizePolymorphism, Single NucleotideQuantitative Trait Lociallele-specific expression (ASE)bone geometrybone strengthQTL fine-mappingquantitative trait loci (QTL)

Identifiers

PMID28082324
PMCPMC5345717

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.