Evidence map›Paper›PMID 28082259›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).

James S Pankow, Weihong Tang, Nathan Pankratz, Weihua Guan, Lu-Chen Weng, Mary Cushman, Eric Boerwinkle, Aaron R Folsom

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Replication of Newly Identified Genetic Associations Between Abdominal Aortic Aneurysm and SMYD2, LINC00540, PCIF1/MMP9/ZNF335, and ERG.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2020
    Pooled it
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  5. Multimodal data integration to predict atrial fibrillation.European heart journal. Digital health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

James S PankowFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.). pankow@umn.edu.
Weihong TangFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Nathan PankratzFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Weihua GuanFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Lu-Chen WengFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Mary CushmanFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Eric BoerwinkleFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
Aaron R FolsomFrom the Division of Epidemiology and Community Health (J.S.P., W.T., L.-C.W., A.R.F.), Department of Laboratory Medicine and Pathology (N.P.), and Division of Biostatistics (W.G.), University of Minnesota, Minneapolis; Department of Medicine (M.C.) and Department of Pathology (M.C.), University of Vermont, Burlington; and Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston (E.B.).
University of Vermont · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7M
BLOOD COAGULATION &FIBRINOLYSISR01HL065226 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI MACKMAN, NIGEL · 2000 to 2004
$1.8M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
Genetic Epidemiological Study of Venous Thromboembolism and Hemostatic FactorsR01HL095603 · NHLBI · UNIVERSITY OF MINNESOTA · PI TANG, WEIHONG · 2009 to 2012
$1.2M
NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS N01 HC065226NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL095603NHLBI NIH HHS RC2 HL102419
6 · The paper itself

Abstract

objectivePrevious studies have identified common genetic variants in 4 chromosomal regions that together account for 14% to 15% of the variance in circulating levels of protein C. To further characterize the genetic architecture of protein C, we obtained denser coverage at some loci, extended investigation of protein C to low-frequency and rare variants, and searched for new associations in genes known to influence protein C. APPROACH AND

resultsGenetic associations with protein C antigen level were evaluated in ≤10 778 European and 3190 black participants aged 45 to 64 years. Analyses included >26 million autosomal variants available after imputation to the 1000 Genomes reference panel along with additional low-frequency and rare variants directly genotyped using the Illumina ITMAT-Broad-CARe chip and Illumina HumanExome BeadChip. Genome-wide significant associations (

conclusionsDiscovery of variants influencing circulating protein C levels in the CELSR2-PSRC1-SORT1 region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

Indexed as

Polymorphism, Single NucleotideAdaptor Proteins, Vesicular TransportAtherosclerosisBlack or African AmericanCadherinsCholesterol, LDLChromosomes, Human, Pair 1FemaleGene Expression ProfilingGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHemostasisHumansMaleMendelian Randomization AnalysisAdaptor Proteins, Vesicular TransportCadherinsCELSR2 protein, humanCholesterol, LDLGenetic MarkersPhosphoproteinsProtein CPSRC1 protein, humanSortilinTriglyceridescholesterol, HDLcholesterol, LDLgenetic association studiesprotein Ctriglycerides

Identifiers

PMID28082259
PMCPMC5376064
OpenAlexW2573510738

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.