Evidence map›Paper›PMID 28081943›Full record

ArticleOphthalmology2017

Capturing the Moment of Fusion Loss in Intermittent Exotropia.

John R Economides, Daniel L Adams, Jonathan C Horton

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Vergence and accommodation responses in the control of intermittent exotropia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Bilateral Occlusion Reduces the Ocular Deviation in Intermittent Exotropia.Investigative ophthalmology & visual science · 2021
    Article
  9. Article
  10. Binocular discrepancy in lateral rectus muscle attachment in intermittent exotropia with eye dominance.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  11. Incomitance and Eye Dominance in Intermittent Exotropia.Investigative ophthalmology & visual science · 2017
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

John R EconomidesDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Daniel L AdamsDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California; Center for Mind/Brain Sciences, The University of Trento, Trento, Italy.
Jonathan C HortonDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: hortonj@vision.ucsf.edu.
University of California, San Francisco · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUSR01EY010217 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HORTON, JONATHAN C · 1993 to 2018
$8.5M
Structural Basis of Amblyopia and StrabismusR56EY010217 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HORTON, JONATHAN C · 2008 to 2008
$369k
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY010217NEI NIH HHS R56 EY010217
6 · The paper itself

Abstract

purposeTo characterize eye movements made by patients with intermittent exotropia when fusion loss occurs spontaneously and to compare them with those induced by covering 1 eye and with strategies used to recover fusion.

designProspective study of a patient cohort referred to our laboratory.

participantsThirteen patients with typical findings of intermittent exotropia who experienced frequent spontaneous loss of fusion.

methodsThe position of each eye was recorded with a video eye tracker under infrared illumination while fixating on a small central near target.

main outcome measuresEye position and peak velocity measured during spontaneous loss of fusion, shutter-induced loss of fusion, and recovery of fusion.

resultsIn 10 of 13 subjects, the eye movement made after spontaneous loss of fusion was indistinguishable from that induced by covering 1 eye. It reached 90% of full amplitude in a mean of 1.75 seconds. Peak velocity of the deviating eye's movement was highly correlated for spontaneous and shutter-induced events. Peak velocity was also proportional to exotropia amplitude. Recovery of fusion was more rapid than loss of fusion, and often was accompanied by interjection of a disconjugate saccade.

conclusionsLoss of fusion in intermittent exotropia is not influenced by visual feedback. Excessive divergence tone may be responsible, but breakdown of alignment occurs via a unique, pathological type of eye movement that differs from a normal, physiological divergence eye movement.

Indexed as

AdolescentAdultChildExotropiaEye Movement MeasurementsFemaleFixation, OcularHumansMaleMiddle AgedOculomotor MusclesOphthalmologic Surgical ProceduresProspective StudiesSaccadesVision, Binocular

Identifiers

PMID28081943
PMCPMC5685669
OpenAlexW2567771752

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.