Evidence map›Paper›PMID 28081781›Full record

ArticleMetabolism: clinical and experimental2017

Effects of visceral adiposity on glycerol pathways in gluconeogenesis.

Ian J Neeland, Connor Hughes, Colby R Ayers, Craig R Malloy, Eunsook S Jin

Registry-linked trialAbstract read
In one paragraph

Article in Metabolism: clinical and experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03480594 (Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03480594 completednot on this mapstarted 2018, after this paper: background citation

Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2018 to 2023Enrolled22ConditionsFatty LiverArmsMRI Tracer
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  13. Observational
  14. Role of waist circumferenceZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ian J NeelandDepartment of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: ian.neeland@utsouthwestern.edu.
Connor HughesDepartment of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Colby R AyersDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Craig R MalloyAdvanced Imaging Research Center and Departments of Internal Medicine and Radiology, University of Texas Southwestern Medical Center and VA North Texas Healthcare System, Dallas, TX, USA.
Eunsook S JinAdvanced Imaging Research Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2012 to 2021
$10.9M
13C asymmetry in blood glucose as a marker for oxidative stress in liverR01DK099289 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JIN, EUNSOOK · 2014 to 2017
$1.1M
Visceral Adiposity and Diabetes: Translating Form to Function Using ImagingK23DK106520 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI NEELAND, IAN JASON · 2015 to 2019
$776k
NIBIB NIH HHS P41 EB015908NIDDK NIH HHS K23 DK106520NIDDK NIH HHS R01 DK099289
6 · The paper itself

Abstract

objectiveTo determine the feasibility of using oral RESEARCH DESIGN AND

methodsObese (BMI ≥30kg/m

resultsMean age, BMI, and baseline glucose were 49years, 40.1kg/m

conclusionsWe applied a simple method to detect gluconeogenesis from glycerol in obese humans. Our findings provide preliminary evidence that excess visceral fat disrupts multiple pathways in hepatic gluconeogenesis from glycerol.

Indexed as

GluconeogenesisAdipose TissueAdiposityAdultAgedBlood GlucoseBody Mass IndexCitric Acid CycleDiabetes Mellitus, Type 2EatingFastingFemaleGlycerolHumansIntra-Abdominal FatMaleBlood GlucoseGlycerolGluconeogenesisGlycerolPentose phosphate pathwayTricarboxylic acid cycleVisceral fat

Identifiers

PMID28081781
PMCPMC5244471
OpenAlexW2550719151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.