Trial reportBMC infectious diseases2017
The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida.
Trial report in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2019Pooled it
- Long-term antibiotics for preventing recurrent urinary tract infection in children.The Cochrane database of systematic reviews · 2019Pooled it
- Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial.The Lancet. Infectious diseases · 2018Trial
- EAU-ESPU-ERN eUROGEN-ERN ITHACA-ERN ERKNet-IFSBH Guidelines on Spinal Dysraphism in Children and Adolescents: Summary of the Guideline.European urology open science · 2026Article
- Effect of prophylactic antibiotics on days of antibiotic spectrum coverage in comatose post-cardiac arrest patients: a secondary analysis of PROTECT.JAC-antimicrobial resistance · 2026Article
- Efficacy of the Roy Adaptation Model with smartphone training in reducing urinary tract infection in pediatric clean intermittent catheterization: a prospective study.European journal of pediatrics · 2025Article
- The urological evaluation and management of neurogenic bladder in children and adolescents-what every pediatric nephrologist needs to know.Pediatric nephrology (Berlin, Germany) · 2024Article
- Review of antibiotic-resistant bacteria and antibiotic resistance genes within the one health framework.Infection ecology & epidemiology · 2024Review
- Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group.Antibiotics (Basel, Switzerland) · 2023Review
- Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia.Children (Basel, Switzerland) · 2022Article
- Article
- Asymptomatic bacteriuria and antibiotic resistance profile in children with neurogenic bladder who require clean intermittent catheterization.Spinal cord · 2022Article
- The impact of constant antibiotic prophylaxis in children affected by spinal dysraphism performing clean intermittent catheterization: a 2-year monocentric retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Trends in Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2020Article
- Association of systemic antimicrobials with the expression of beta-lactamases in bacteria cultured from urological patients.Diagnostic microbiology and infectious disease · 2019Article
- Erratum to: The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida.BMC infectious diseases · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial resistance to antibiotics is an increasingly threatening consequence of antimicrobial exposure for many decades now. In urinary tract infections (UTIs), antibiotic prophylaxis (AP) increases bacterial resistance. We studied the resistance patterns of positive urinary cultures in spina bifida children on clean intermittent catheterization, both continuing and stopping AP.
methodsIn a cohort of 176 spina bifida patients, 88 continued and 88 stopped using AP. During 18 months, a fortnightly catheterized urine sample for bacterial pathogens was cultured. UTIs and significant bacteriuria (SBU) were defined as a positive culture with a single species of bacteria, respectively with and without clinical symptoms and leukocyturia. We compared the percentage of resistance to commonly used antibiotics in the isolated bacteria in both groups.
resultsIn a total of 4917 cultures, 713 (14.5%) had a positive monoculture, 54.3% of which were Escherichia coli. In the group stopping AP, the resistance percentage to antibiotics in UTI / SBU bacteria was lower than in the group remaining on AP, even when excluding the administered prophylaxis.
conclusionStopping antibiotic prophylaxis for urinary tract infections is associated with reduced bacterial resistance to antibiotics in children with spina bifida.
trial registrationISRCTN ISRCTN56278131 . Registered 20 December 2005.
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