Evidence map›Paper›PMID 28081371›Full record

SynthesisJournal of dental research2017

GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.

A E Sanders, D Jain, T Sofer, K F Kerr, C C Laurie, J R Shaffer, M L Marazita, L M Kaste, G D Slade, R B Fillingim and 17 more

Abstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. The Era of the Genome and Dental Medicine.Journal of dental research · 2019
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 13 institutions in 5 countries.

A E Sanders1 Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
D Jain3 Department of Biostatistics, University of Washington, Seattle, WA, USA.
T Sofer3 Department of Biostatistics, University of Washington, Seattle, WA, USA.
K F Kerr3 Department of Biostatistics, University of Washington, Seattle, WA, USA.
C C Laurie3 Department of Biostatistics, University of Washington, Seattle, WA, USA.
J R Shaffer4 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
M L Marazita4 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
L M Kaste10 Department of Pediatric Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
G D Slade11 Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
R B Fillingim12 Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
R Ohrbach13 Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA.
W Maixner14 Department of Anesthesiology, Center for Translational Pain Medicine, Duke University, Durham, NC, USA.
T Kocher15 Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
O Bernhardt15 Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
A Teumer16 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
C Schwahn17 Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University Medicine Greifswald, Greifswald, Germany.
K Sipilä18 Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
R Lähdesmäki20 Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
M Männikkö23 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
P Pesonen20 Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
M Järvelin25 Biocenter Oulu, University of Oulu, Center for Life Course Health Research, University of Oulu, Finland.
C M Rizzatti-Barbosa27 Department of Prosthesis and Periodontology, Piracicaba Dental Scholl, University of Campinas, Piracicaba, Brazil.
C B Meloto28 The Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, QC, Canada.
M Ribeiro-Dasilva29 University of Florida, College of Dentistry, Gainesville, FL, USA.
L Diatchenko30 Alan Edwards Pain Centre, McGill University, Montreal, QC, Canada.
P Serrano31 Piracicaba Dental School, State University of Campinas, Department of Prosthesis and Periodontology, Brazil.
S B Smith14 Department of Anesthesiology, Center for Translational Pain Medicine, Duke University, Durham, NC, USA.
Universitätsmedizin Greifswald · DEUniversity of Washington · USUniversity of Florida · USUniversity of Oulu · FIDuke University · USOulu University Hospital · FIUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Pittsburgh · USMcGill University · CAMcGill University Health Centre · CAUniversity at Buffalo, State University of New York · USUniversity of Illinois Chicago · USUniversity of North Carolina at Chapel Hill · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Risk Factors for Onset and Persistence of TMDU01DE017018 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIATCHENKO, LUDA, FILLINGIM, ROGER B · 2005 to 2016
$35.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Genetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0M
Genetic Influences on ADHD in a Finnish Birth CohortR01MH063706 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALLEY, SUSAN L · 2001 to 2005
$3.3M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
Leveraging ancestral diversity to map adiposity loci in HispanicsR01DK101855 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAIMAN, CHRISTOPHER ALAN, LOOS, RUTH JF · 2014 to 2016
$2.1M
Whole Genome Assoc. Analysis Strategies for Multi. PhenotypesRL1MH083268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$2.1M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL087679NIA NIH HHS P30 AG028740NIDCR NIH HHS U01 DE017018NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK101855NIMH NIH HHS R01 MH063706NIMH NIH HHS RL1 MH083268
6 · The paper itself

Abstract

Temporomandibular disorder (TMD) is a musculoskeletal condition characterized by pain and reduced function in the temporomandibular joint and/or associated masticatory musculature. Prevalence in the United States is 5% and twice as high among women as men. We conducted a discovery genome-wide association study (GWAS) of TMD in 10,153 participants (769 cases, 9,384 controls) of the US Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The most promising single-nucleotide polymorphisms (SNPs) were tested in meta-analysis of 4 independent cohorts. One replication cohort was from the United States, and the others were from Germany, Finland, and Brazil, totaling 1,911 TMD cases and 6,903 controls. A locus near the sarcoglycan alpha ( SGCA), rs4794106, was suggestive in the discovery analysis ( P = 2.6 × 10

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotideBrazilCase-Control StudiesDystrophinFemaleFinlandGenetic LociGenetic Predisposition to DiseaseGenotypeGermanyHispanic or LatinoHumansMalePhenotypePrevalenceDMD protein, humanDystrophinReceptors, G-Protein-CoupledRXFP2 protein, humanSarcoglycansSGCA protein, humanSP4 protein, humanSp4 Transcription Factorepidemiologyfunctional annotationgeneticsHispanic Americansmusculoskeletal painpopulation

Identifiers

PMID28081371
PMCPMC5298397
OpenAlexW2577841140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.