Evidence map›Paper›PMID 28081369›Full record

Trial reportAmerican journal of respiratory and critical care medicine2017

Randomized Controlled Ethanol Cookstove Intervention and Blood Pressure in Pregnant Nigerian Women.

Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02394574 (Household Air Pollution and Pregnancy Outcome), which is not on this map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02394574 nacompletednot on this map

Household Air Pollution and Pregnancy Outcome

TypeinterventionalSponsorUniversity of ChicagoRan2012 to 2015Enrolled307ConditionsPregnancyArmsClean Cookstove, Traditional Cookstove
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Donee Alexander1 Center for Global Health.
Amanda Northcross2 Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia.
Nathaniel Wilson3 Pritzker School of Medicine.
Anindita Dutta1 Center for Global Health.
Rishi Pandya5 Bellevue Hospital Center, New York, New York.
Tope Ibigbami6 Healthy Life for All Foundation, Ibadan, Nigeria; and.
Damilola Adu6 Healthy Life for All Foundation, Ibadan, Nigeria; and.
John Olamijulo6 Healthy Life for All Foundation, Ibadan, Nigeria; and.
Oludare Morhason-Bello7 Department of Obstetrics and Gynecology, University of Ibadan, Ibadan, Nigeria.
Theodore Karrison8 Department of Public Health Sciences, University of Chicago, Chicago, Illinois.
Oladosu Ojengbede7 Department of Obstetrics and Gynecology, University of Ibadan, Ibadan, Nigeria.
Christopher O Olopade1 Center for Global Health.ORCID 0000-0002-4243-1488
University of Ibadan · NGCenter for Global Health · USBellevue Hospital Center · USChicago Department of Public Health · USMilken Institute · USPritzker Traubert Family Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleHypertension during pregnancy is a leading cause of maternal mortality. Exposure to household air pollution elevates blood pressure (BP).

objectivesTo investigate the ability of a clean cookstove intervention to lower BP during pregnancy.

methodsWe conducted a randomized controlled trial in Nigeria. Pregnant women cooking with kerosene or firewood were randomly assigned to an ethanol arm (n = 162) or a control arm (n = 162). BP measurements were taken during six antenatal visits. In the primary analysis, we compared ethanol users with control subjects. In subgroup analyses, we compared baseline kerosene users assigned to the intervention with kerosene control subjects and compared baseline firewood users assigned to ethanol with firewood control subjects. MEASUREMENTS AND MAIN

resultsThe change in diastolic blood pressure (DBP) over time was significantly different between ethanol users and control subjects (P = 0.040); systolic blood pressure (SBP) did not differ (P = 0.86). In subgroup analyses, there was no significant intervention effect for SBP; a significant difference for DBP (P = 0.031) existed among preintervention kerosene users. At the last visit, mean DBP was 2.8 mm Hg higher in control subjects than in ethanol users (3.6 mm Hg greater in control subjects than in ethanol users among preintervention kerosene users), and 6.4% of control subjects were hypertensive (SBP ≥140 and/or DBP ≥90 mm Hg) versus 1.9% of ethanol users (P = 0.051). Among preintervention kerosene users, 8.8% of control subjects were hypertensive compared with 1.8% of ethanol users (P = 0.029).

conclusionsTo our knowledge, this is the first cookstove randomized controlled trial examining prenatal BP. Ethanol cookstoves have potential to reduce DBP and hypertension during pregnancy. Accordingly, clean cooking fuels may reduce adverse health impacts associated with household air pollution. Clinical trial registered with www.clinicaltrials.gov (NCT02394574).

Indexed as

Blood PressureEthanolAdultCookingFemaleHumansHypertensionKeroseneNigeriaPregnancyPregnancy Complications, CardiovascularWoodEthanolKeroseneblood pressureethanol cookstove interventionhousehold air pollutionhypertensionpregnancy

Identifiers

PMID28081369
OpenAlexW2581558375

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.