ArticlePloS one2017
Osmoregulation in the Halophilic Bacterium Halomonas elongata: A Case Study for Integrative Systems Biology.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Integrated Physiological, Transcriptomic, and Gut Microbial Responses of Chinese Mitten Crab (Eriocheir sinensis) to Acute Salinity Stress.Marine biotechnology (New York, N.Y.) · 2026Article
- The LuxS/AI-2 quorum sensing system regulates osmotic adaptation, motility, and type VI secretion system inFrontiers in microbiology · 2026Article
- Decoding metabolic trade-offs inSynthetic and systems biotechnology · 2025Article
- Establishing Halomonas as a chassis for industrial biotechnology: advances in synthetic biology tool development and metabolic engineering strategies.Microbial cell factories · 2025Review
- Enhanced accumulation of γ-aminobutyric acid by deletion of aminotransferase genes involved in γ-aminobutyric acid catabolism in engineeredApplied and environmental microbiology · 2024Article
- Metabolic modeling of Halomonas campaniensis improves polyhydroxybutyrate production under nitrogen limitation.Applied microbiology and biotechnology · 2024Article
- Temporal dynamics of stress response in Halomonas elongata to NaCl shock: physiological, metabolomic, and transcriptomic insights.Microbial cell factories · 2024Article
- Metabolic engineering of high-salinity-induced biosynthesis of γ-aminobutyric acid improves salt-stress tolerance in a glutamic acid-overproducing mutant of an ectoine-deficientApplied and environmental microbiology · 2024Article
- Study on the intracellular adaptative mechanism of Acidithiobacillus caldus MTH-04 to NaCl stress.Microbial cell factories · 2023Article
- Article
- Co-Production of Poly(3-hydroxybutyrate) and Gluconic Acid from Glucose byBioengineering (Basel, Switzerland) · 2023Article
- Identification of novel halophilic/halotolerant bacterial species producing compatible solutes.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Microbial community structure and exploration of bioremediation enzymes: functional metagenomics insight into Arabian Sea sediments.Molecular genetics and genomics : MGG · 2023Article
- Characterization and Expression Analysis of Extradiol and Intradiol Dioxygenase of Phenol-Degrading Haloalkaliphilic Bacterial Isolates.Current microbiology · 2022Article
- Immunostimulant Activity of Bacteria Isolated from Extreme Environments in Baja California Sur, Mexico: A Bioprospecting Approach.Indian journal of microbiology · 2022Article
- Whole genome sequencing of the halophilic Halomonas qaidamensis XH36, a novel species strain with high ectoine production.Antonie van Leeuwenhoek · 2022Article
- Study of osmoadaptation mechanisms of halophilic Halomonas alkaliphila XH26 under salt stress by transcriptome and ectoine analysis.Extremophiles : life under extreme conditions · 2022Article
- Draft Genome Sequence of a Bacterium Isolated from Hypersaline Soil in Sonora, Mexico:Microbiology resource announcements · 2022Article
- Adaptation to Varying Salinity inFrontiers in microbiology · 2022Article
- Net Charges of the Ribosomal Proteins of theMicrobiology spectrum · 2021Article
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10 authors.
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Abstract
Halophilic bacteria use a variety of osmoregulatory methods, such as the accumulation of one or more compatible solutes. The wide diversity of compounds that can act as compatible solute complicates the task of understanding the different strategies that halophilic bacteria use to cope with salt. This is specially challenging when attempting to go beyond the pathway that produces a certain compatible solute towards an understanding of how the metabolic network as a whole addresses the problem. Metabolic reconstruction based on genomic data together with Flux Balance Analysis (FBA) is a promising tool to gain insight into this problem. However, as more of these reconstructions become available, it becomes clear that processes predicted by genome annotation may not reflect the processes that are active in vivo. As a case in point, E. coli is unable to grow aerobically on citrate in spite of having all the necessary genes to do it. It has also been shown that the realization of this genetic potential into an actual capability to metabolize citrate is an extremely unlikely event under normal evolutionary conditions. Moreover, many marine bacteria seem to have the same pathways to metabolize glucose but each species uses a different one. In this work, a metabolic network inferred from genomic annotation of the halophilic bacterium Halomonas elongata and proteomic profiling experiments are used as a starting point to motivate targeted experiments in order to find out some of the defining features of the osmoregulatory strategies of this bacterium. This new information is then used to refine the network in order to describe the actual capabilities of H. elongata, rather than its genetic potential.
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