ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus Cryptococcus gattii.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Article
- Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis.PLoS pathogens · 2023Article
- Intestinal bacteria-a powerful weapon for fungal infections treatment.Frontiers in cellular and infection microbiology · 2023Review
- Gene, virulence and related regulatory mechanisms inActa biochimica et biophysica Sinica · 2022Review
- Article
- Metagenomic next-generation sequencing assists in the diagnosis ofFrontiers in public health · 2022Review
- Molecular Markers Reveal Epidemiological Patterns and Evolutionary Histories of the Human PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections.Life (Basel, Switzerland) · 2020Review
- Interactions between invasive fungi and symbiotic bacteria.World journal of microbiology & biotechnology · 2020Review
- Pathogen and host genetics underpinning cryptococcal disease.Advances in genetics · 2020Review
- A New Lineage of Cryptococcus gattii (VGV) Discovered in the Central Zambezian Miombo Woodlands.mBio · 2019Article
- Transcriptional Heterogeneity ofmSphere · 2018Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Conservation of Intracellular Pathogenic Strategy among Distantly Related Cryptococcal Species.Infection and immunity · 2018Article
- Genotypic and Phenotypic Diversity ofFrontiers in microbiology · 2018Article
- Estimating the Intra-taxa Diversity, Population Genetic Structure, and Evolutionary Pathways ofFrontiers in genetics · 2018Article
- Advances in Cryptococcus genomics: insights into the evolution of pathogenesis.Memorias do Instituto Oswaldo Cruz · 2018Review
- Article
- Tackling emerging fungal threats to animal health, food security and ecosystem resilience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Emerging fungal pathogens cause an expanding burden of disease across the animal kingdom, including a rise in morbidity and mortality in humans. Yet, we currently have only a limited repertoire of available therapeutic interventions. A greater understanding of the mechanisms of fungal virulence and of the emergence of hypervirulence within species is therefore needed for new treatments and mitigation efforts. For example, over the past decade, an unusual lineage of Cryptococcus gattii, which was first detected on Vancouver Island, has spread to the Canadian mainland and the Pacific Northwest infecting otherwise healthy individuals. The molecular changes that led to the development of this hypervirulent cryptococcal lineage remain unclear. To explore this, we traced the history of similar microevolutionary events that can lead to changes in host range and pathogenicity. Here, we detail fine-resolution mapping of genetic differences between two highly related Cryptococcus gattii VGIIc isolates that differ in their virulence traits (phagocytosis, vomocytosis, macrophage death, mitochondrial tubularization and intracellular proliferation). We identified a small number of single site variants within coding regions that potentially contribute to variations in virulence. We then extended our methods across multiple lineages of C. gattii to study how selection is acting on key virulence genes within different lineages.This article is part of the themed issue 'Tackling emerging fungal threats to animal health, food security and ecosystem resilience'.
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