SynthesisPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis.
Synthesis in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.The American journal of psychiatry · 2021Pooled it
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- An interoceptive model of bulimia nervosa: A neurobiological systematic review.Journal of psychiatric research · 2017Pooled it
- One's Interoception Affects the Representation of Seeing Others' Pain: A Randomized Controlled qEEG Study.Pain research & management · 2021Trial
- Functional neuroanatomy of interoceptive processing in children and adolescents: a pilot study.Scientific reports · 2019Trial
- High-dose ondansetron reduces activation of interoceptive and sensorimotor brain regions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Embodied Interoception Questionnaire (Intero-10): Development, Validation, and Application in People With Neuropathic Chronic Pain.European journal of pain (London, England) · 2026Article
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Altered dorsal anterior insula functional connectivity underlying abnormal interoceptive accuracy awareness in migraine without aura.The journal of headache and pain · 2026Article
- Brain structural correlates of individual differences in heartbeat counting and discrimination: A voxel-based morphometry study.Scientific reports · 2026Article
- When attention falters: brain, breathing, and behavioral signals of lapses in interoceptive attention.bioRxiv : the preprint server for biology · 2026Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Assessing health, wellbeing, and working life impacts of a 4-day week: a multimodal protocol.Frontiers in psychology · 2026Article
- Attenuated heartbeat-evoked potentials in functional neurological disorder.Brain communications · 2026Article
- Autonomic Imbalance in Cardiomyopathy and Heart Failure: From Neurobiology to Precision Neuromodulation.Current cardiology reports · 2025Review
- Article
- Morphometric Evidence of a U-Shaped Relationship Between Loss Aversion and Posterior Insular/Somatosensory Cortical Features.Human brain mapping · 2025Article
- Graded changes in local functional connectivity of the cerebral cortex in young people with depression.Psychological medicine · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interoception is the ability to perceive one's internal body state including visceral sensations. Heart-focused interoception has received particular attention, in part due to a readily available task for behavioural assessment, but also due to accumulating evidence for a significant role in emotional experience, decision-making and clinical disorders such as anxiety and depression. Improved understanding of the underlying neural correlates is important to promote development of anatomical-functional models and suitable intervention strategies. In the present meta-analysis, nine studies reporting neural activity associated with interoceptive attentiveness (i.e. focused attention to a particular interoceptive signal for a given time interval) to one's heartbeat were submitted to a multilevel kernel density analysis. The findings corroborated an extended network associated with heart-focused interoceptive attentiveness including the posterior right and left insula, right claustrum, precentral gyrus and medial frontal gyrus. Right-hemispheric dominance emphasizes non-verbal information processing with the posterior insula presumably serving as the major gateway for cardioception. Prefrontal neural activity may reflect both top-down attention deployment and processing of feed-forward cardioceptive information, possibly orchestrated via the claustrum.This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.
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