Evidence map›Paper›PMID 28080040›Full record

ArticleJournal of the American Chemical Society2017

Insights into Thiol-Aromatic Interactions: A Stereoelectronic Basis for S-H/π Interactions.

Christina R Forbes, Sudipta K Sinha, Himal K Ganguly, Shi Bai, Glenn P A Yap, Sandeep Patel, Neal J Zondlo

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Catechol redox maintenance in mussel adhesion.Nature reviews. Chemistry · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. NMR Observation of Sulfhydryl Signals in SARS-CoV-2 Main Protease Aids Structural Studies.Chembiochem : a European journal of chemical biology · 2022
    Article
  16. Article
  17. Article
  18. Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 MEuropean journal of medicinal chemistry reports · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christina R ForbesDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Sudipta K SinhaDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Himal K GangulyDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Shi BaiDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Glenn P A YapDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Sandeep PatelDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Neal J ZondloDepartment of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.ORCID 0000-0002-7417-8085
University of Delaware · US

Funding

Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2014 to 2018
$5.8M
Novel Protein SensorsR01GM093225 · NIGMS · UNIVERSITY OF DELAWARE · PI ZONDLO, NEAL J · 2010 to 2014
$1.4M
NIGMS NIH HHS P30 GM110758NIGMS NIH HHS R01 GM093225
6 · The paper itself

Abstract

Thiols can engage favorably with aromatic rings in S-H/π interactions, within abiological systems and within proteins. However, the underlying bases for S-H/π interactions are not well understood. The crystal structure of Boc-l-4-thiolphenylalanine tert-butyl ester revealed crystal organization centered on the interaction of the thiol S-H with the aromatic ring of an adjacent molecule, with a through-space H

Indexed as

Quantum TheoryCrystallography, X-RayHydrocarbons, AromaticModels, MolecularMolecular StructureStereoisomerismSulfhydryl CompoundsHydrocarbons, AromaticSulfhydryl Compounds

Identifiers

PMID28080040
PMCPMC5890429
OpenAlexW2575949251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.