ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Cerebral modulation of the autonomic nervous system in term infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Continuous autonomic system monitoring during neurosurgical procedures -proof of concept.Journal of clinical monitoring and computing · 2026Article
- Apnoea suppresses brain activity in infants.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury.Pediatric research · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Cerebral cortical autonomic connectivity in low-risk term newborns.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Identifying an optimal epoch length for spectral analysis of heart rate of critically-ill infants.Computers in biology and medicine · 2019Article
- The effect of unilateral stroke on autonomic function in the term newborn.Pediatric research · 2019Article
- The Critical Role of the Central Autonomic Nervous System in Fetal-Neonatal Transition.Seminars in pediatric neurology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCentral topography of autonomic nervous system (ANS) function has yet to be fully deciphered. In adults it has been shown to lateralize sympathetic and parasympathetic influence predominantly to the right and left cerebral hemispheres, respectively. We examined functional topography of central ANS in newborn subjects utilizing spectral analysis of heart rate variability (HRV), an established measure of ANS function. STUDY
designWe studied newborns with hypoxic-ischemic encephalopathy participating in a prospective study undergoing a therapeutic hypothermia protocol.We included subjects with continuous heart rate data over the first 3 h of normothermia (post rewarming) and brain magnetic resonance imaging, which was reviewed and scored according to a 4 region scheme. HRV was evaluated by spectral analysis in the low-frequency (0.05 to 0.25 Hz) and high-frequency (0.3 to 1 Hz) ranges. The relationship between injured brain regions and HRV was studied using multiple regressions.
resultsForty eight newborns were included. When examined in isolation, right hemisphere injury had a significant negative effect on HRV (-0.088; 95% CI: -0.225,-0.008). The combination of posterior fossa region injury with right hemispheric injury or left hemispheric injury demonstrated significant positive (0.299; 95% CI: 0.065, 0.518) and negative (-0.475; 95% CI: -0.852, -0.128) influences on HRV, respectively. The association between brain injury location and HRV in the high-frequency range did not reach significance.
conclusionOur data support the notion that lateralized cerebral modulation of the ANS, specifically of its sympathetic component, is present in the term newborn, and suggest complex modulation of these tracts by components of the posterior fossa.
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