Evidence map›Paper›PMID 28079864›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2017

Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis.

G Al-Ghanem, P Shah, S Thomas, L Banfield, S El Helou, C Fusch, A Mukerji

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. [A Meta analysis of risk factors for pulmonary hypertension related to bronchopulmonary dysplasia in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Pooled it
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  5. Natriuretic peptides in bronchopulmonary dysplasia: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Pooled it
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  14. Observational
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  18. Assessing the role of tracheostomy placement in bronchopulmonary dysplasia with pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

G Al-GhanemDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
P ShahDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
S ThomasDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
L BanfieldDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
S El HelouDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
C FuschDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
A MukerjiDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
McMaster University · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePulmonary hypertension (PH) is a complication of bronchopulmonary dysplasia (BPD) but the true impact of PH in patients with BPD remains unclear. We sought to systematically review and meta-analyze incidence of PH in BPD and compare clinical outcomes of BPD patients with PH to those without PH in preterm infants. STUDY

designMedline, Embase, PsychINFO and CINAHL were searched from January 2000 through December 2015. Cohort, case-control and randomized studies were included. Case-reports, case-series and letters to editors and studies with high risk of bias were excluded. Study design, inclusion/exclusion criteria, diagnostic criteria for BPD and PH and outcomes were extracted independently by two co-authors.

resultsThe pooled incidence of PH in patients with BPD (any severity) was 17% (95% confidence interval (CI) 12 to 21; 7 studies) and 24% (95% CI 17 to 30; 9 studies) in moderate-severe BPD. Patients with BPD have higher unadjusted odds of developing PH compared to those without BPD (odds ratio (OR) 3.00; 95% CI 1.18 to 7.66; 4 studies). Patients with BPD and PH were at higher odds of mortality (OR 5.29; 95% CI 2.07 to 13.56; 3 studies) compared with BPD without PH, but there was no significant difference in duration of initial hospitalization, duration of supplemental oxygen requirement or need for home oxygen. No studies included in this review reported on long-term pulmonary or neurodevelopmental outcomes.

conclusionsPH occurs in one out of 4 to 5 preterm neonates with BPD. Patients with BPD and PH may have higher odds of mortality; however, there is urgent need for high quality studies that control for confounders and provide data on long-term outcomes.

Indexed as

Bronchopulmonary DysplasiaHumansHypertension, PulmonaryInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLung

Identifiers

PMID28079864
OpenAlexW2575795102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.