Evidence map›Paper›PMID 28079560›Full record

ReviewCurrent opinion in allergy and clinical immunology2017

Prenatal exposures and the development of childhood wheezing illnesses.

Christian Rosas-Salazar, Tina V Hartert

Abstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Childhood Asthma: Is It All About Bacteria and Not About Viruses? A Pro/Con Debate.The journal of allergy and clinical immunology. In practice
    Review
  12. As You Eat It: Effects of Prenatal Nutrition on Asthma.The journal of allergy and clinical immunology. In practice
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christian Rosas-SalazaraDivision of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics bDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine cCenter for Asthma Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Tina V Hartert

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Christian Rosas-Salazar · 2011 to 2026
$34.9M
Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & AsthmaK24AI077930 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTERT, TINA V · 2008 to 2017
$1.6M
NIAID NIH HHS K24 AI077930NIAID NIH HHS U19 AI095227
6 · The paper itself

Abstract

purpose of reviewTo critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT

findingsThe aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes. There is insufficient evidence to support an association between in-utero exposure to acetaminophen or prenatal levels of specific nutrients (such as vitamin D, folic acid, or polyunsaturated fatty acids) and childhood wheezing illnesses. SUMMARY: Several common potentially modifiable prenatal exposures appear to be consistently associated with childhood wheezing illnesses (e.g. parental smoking, outdoor air pollution, and maternal stress). However, the effect of many other prenatal exposures on the onset of childhood wheezing illnesses remains unclear. The existing scientific evidence from the past year does not allow us to make any new recommendations on primary prevention measures. Intervention studies will best demonstrate whether changing the prenatal environment can prevent childhood wheezing illnesses and asthma.

Indexed as

Maternal ExposureAir PollutionAnimalsAsthmaChildFemaleHumansPregnancyPrenatal Exposure Delayed EffectsRespiratory SoundsSmokingStress, Physiological

Identifiers

PMID28079560
PMCPMC5559872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.