ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Maternal physical activity levels in early pregnancy and the risk of spinal deformity among preschoolers at age 4: findings from the Shanghai birth cohort study.Frontiers in pediatrics · 2025Article
- Embryo movement is required for limb tendon maturation.Frontiers in cell and developmental biology · 2024Article
- Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth.bioRxiv : the preprint server for biology · 2023Article
- Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Disrupted tenogenesis in masseter as a potential cause of micrognathia.International journal of oral science · 2022Article
- Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice.European cells & materials · 2021Article
- Exploring infant hip position and muscle activity in common baby gear and orthopedic devices.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Mechanical StimulationFrontiers in cell and developmental biology · 2021Article
- Positioning and baby devices impact infant spinal muscle activity.Journal of biomechanics · 2020Article
- The mutational burden and oligogenic inheritance in Klippel-Feil syndrome.BMC musculoskeletal disorders · 2020Article
- Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.Nature reviews. Rheumatology · 2020Review
- Perinatal factors associate with vertebral size and shape but not lumbar lordosis in 10-year-old children.Journal of anatomy · 2019Article
- Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies.Annals of the New York Academy of Sciences · 2019Review
- Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development.European cells & materials · 2019Article
- Blocking mechanosensitive ion channels eliminates the effects of applied mechanical loading on chick joint morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The mechanical impact ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Mechanical regulation of musculoskeletal system development.Development (Cambridge, England) · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The incidence of congenital spine deformities, including congenital scoliosis, kyphosis, and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation, and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick. The critical time-points for the influence of fetal movements on spinal development were identified by varying the time of onset of paralysis. Prolonged rigid paralysis induced severe defects in the spine, including curvature abnormalities, posterior and anterior vertebral fusions, and altered vertebral shape, while flaccid paralysis did not affect spinal curvature or vertebral segmentation. Early rigid paralysis resulted in more severe abnormalities in the spine than later rigid paralysis. The findings of this study support the hypothesis that the timing and nature of fetal muscle activity are critical influences on the normal development of the spine, with implications for the understanding of congenital spine deformities. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2135-2144, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.