ArticleScientific reports2017
25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Trial
- Association of vitamin D with sepsis incidence and mortality: a large population-based prospective cohort study.Critical care (London, England) · 2026Article
- Determining the Relationship Between Maternal and Neonatal Vitamin D Serum Levels in Term Infants With and Without Sepsis.Journal of family & reproductive health · 2025Article
- Factors Associated with Vitamin A and Vitamin D Profiles among Stunted Children in Bogor, Indonesia.Medical journal of the Islamic Republic of Iran · 2025Article
- Calcitriol in Sepsis-A Single-Centre Randomised Control Trial.Journal of clinical medicine · 2024Article
- Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study.Frontiers in genetics · 2024Article
- The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients.Reports of biochemistry & molecular biology · 2023Article
- Prevalence and Outcome of Secondary Hemophagocytic Lymphohistiocytosis Among SIRS Patients: Results from a Prospective Cohort Study.Journal of clinical medicine · 2019Article
- Article
- Vitamin D status and its influence on outcomes following major burn injury and critical illness.Burns & trauma · 2018Review
- Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis.Children (Basel, Switzerland) · 2017Article
- Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19.Nutrition (Burbank, Los Angeles County, Calif.)Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated. Bacteraemic patients (28.5%) presented with significantly lower 1,25(OH)D levels than SIRS patients without bacteraemia on the first and third day, while 25(OH)D did not show a predictive capacity. No significant differences of either 1,25(OH)D or 25(OH)D levels were found between SIRS patients with and without infections or between survivors and non-survivors. Sepsis biomarkers, including procalcitonin and CRP, showed a significantly higher discriminatory capacity for these classification tasks. The vitamin D metabolism-related SNPs analysed did not indicate any association with our outcome measures. In conclusion, 1,25(OH)D but not 25(OH)D showed a minor discriminatory value for the prediction of bacteraemia that was inferior to CRP and PCT but both failed to predict sepsis and mortality in a prospective cohort of SIRS patients.
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