Evidence map›Paper›PMID 28079169›Full record

SynthesisScientific reports2017

Abnormalities of regional brain function in Parkinson's disease: a meta-analysis of resting state functional magnetic resonance imaging studies.

PingLei Pan, Yang Zhang, Yi Liu, He Zhang, DeNing Guan, Yun Xu

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03439163 (Large Sample Collection for Observation of PD Patients and Healthy Controls), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03439163 completednot on this map

Large Sample Collection for Observation of PD Patients and Healthy Controls

TypeobservationalSponsorXuanwu Hospital, BeijingRan2011 to 2016Enrolled132ConditionsNeuro-Degenerative DiseaseArmsMRI scan
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Altered regional spontaneous brain activity in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

PingLei PanDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
Yang ZhangDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
Yi LiuDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
He ZhangDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
DeNing GuanDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
Yun XuDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
Nanjing Drum Tower Hospital · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is convincing evidence that abnormalities of regional brain function exist in Parkinson's disease (PD). However, many resting-state functional magnetic resonance imaging (rs-fMRI) studies using amplitude of low-frequency fluctuations (ALFF) have reported inconsistent results about regional spontaneous neuronal activity in PD. Therefore, we conducted a comprehensive meta-analysis using the Seed-based d Mapping and several complementary analyses. We searched PubMed, Embase, and Web of Science databases for eligible whole-brain rs-fMRI studies that measured ALFF differences between patients with PD and healthy controls published from January 1st, 2000 until June 24, 2016. Eleven studies reporting 14 comparisons, comparing 421 patients and 381 healthy controls, were included. The most consistent and replicable findings in patients with PD compared with healthy controls were identified, including the decreased ALFFs in the bilateral supplementary motor areas, left putamen, left premotor cortex, and left inferior parietal gyrus, and increased ALFFs in the right inferior parietal gyrus. The altered ALFFs in these brain regions are related to motor deficits and compensation in PD, which contribute to understanding its neurobiological underpinnings and could serve as specific regions of interest for further studies.

Indexed as

Magnetic Resonance ImagingRestAgedBrainCase-Control StudiesFemaleHumansMaleMiddle AgedParkinson DiseaseRegression Analysis

Identifiers

PMID28079169
PMCPMC5228032
OpenAlexW2573142935

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.